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Association between...
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Emilsson, Össur IngiUppsala universitet,Lung- allergi- och sömnforskning
(author)
Association between lung function decline and obstructive sleep apnoea: the ALEC study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-07-06
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/294930
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https://gup.ub.gu.se/publication/294930URI
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https://doi.org/10.1007/s11325-020-02086-1DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173599URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430629URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Purpose To study changes in lung function among individuals with a risk of obstructive sleep apnoea (OSA), and if asthma affected this relationship. Methods We used data from the European Community Respiratory Health Survey II and III, a multicentre general population study. Participants answered questionnaires and performed spirometry at baseline and 10-year follow-up (n= 4,329 attended both visits). Subjects with high risk for OSA were identified from the multivariable apnoea prediction (MAP) index, calculated from BMI, age, gender, and OSA symptoms at follow-up. Asthma was defined as having doctor's diagnosed asthma at follow-up. Primary outcomes were changes in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from baseline to follow-up. Results Among 5108 participants at follow-up, 991 (19%) had a high risk of OSA based on the MAP index. Participants with high OSA risk more often had wheeze, cough, chest tightness, and breathlessness at follow-up than those with low OSA risk. Lung function declined more rapidly in subjects with high OSA risk (low vs high OSA risk [mean +/- SD]: FEV1 = - 41.3 +/- 24.3 ml/year vs - 50.8 +/- 30.1 ml/year; FVC = - 30.5 +/- 31.2 ml/year vs - 45.2 +/- 36.3 ml/year). Lung function decline was primarily associated with higher BMI and OSA symptoms. OSA symptoms had a stronger association with lung function decline among asthmatics, compared to non-asthmatics. Conclusion In the general population, a high probability of obstructive sleep apnoea was related to faster lung function decline in the previous decade. This was driven by a higher BMI and more OSA symptoms among these subjects. The association between OSA symptoms and lung function decline was stronger among asthmatics.
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Sundbom, FredrikUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)fresu433
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Ljunggren, MirjamUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)mirlj221
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Benediktsdottir, B.
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Garcia-Aymerich, J.
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Bui, D. S.
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Jarvis, D.
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Olin, Anna-Carin,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xolina
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Franklin, Karl A.Umeå universitet,Kirurgi(Swepub:umu)kafr0021
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Demoly, P.
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Lindberg, EvaUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)evalb
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
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Aspelund, T.
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Gislason, T.
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Uppsala universitetLung- allergi- och sömnforskning
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In:Sleep and Breathing: Springer Science and Business Media LLC25, s. 587-5961520-95121522-1709
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Jarvis, D.
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Olin, Anna-Carin ...
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