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Circulating apoE4 protein levels from dried blood spots predict cognitive function in a large population-based survey setting

Deza-Lougovski, Yacila I. (författare)
Institute of Psychology, University of the Bundeswehr München, Neubiberg, Germany; Max Planck Institute for Social Law and Social Policy, Munich, Germany
Weiss, Luzia M. (författare)
Max Planck Institute for Social Law and Social Policy, Munich, Germany
Horton, Hannah M. (författare)
Max Planck Institute for Social Law and Social Policy, Munich, Germany; Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA), Munich, Germany
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Sun, Aijing (författare)
Max Planck Institute for Social Law and Social Policy, Munich, Germany; Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA), Munich, Germany
Borbye-Lorenzen, Nis (författare)
Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark
Skogstrand, Kristin (författare)
Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark
Holmgaard, Solveig (författare)
Department for Congenital Disorders, Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark
Andersen-Ranberg, Karen (författare)
Department of Public Health Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark; Department of Clinical Research Geriatric Research Unit, University of Southern Denmark, Odense, Denmark
Panes Lundmark, Vania (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
Börsch-Supan, Axel (författare)
Max Planck Institute for Social Law and Social Policy, Munich, Germany; Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA), Munich, Germany
Börsch-Supan, Martina (författare)
Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA), Munich, Germany; Survey of Health, Ageing and Retirement in Europe (SHARE Biomarker Project), Munich, Germany
Rieckmann, Anna (författare)
Institute of Psychology, University of the Bundeswehr München, Neubiberg, Germany; Max Planck Institute for Social Law and Social Policy, Munich, Germany
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • INTRODUCTION: The apolipoprotein E (APOE) ε4 allele carries risk for cognitive impairment, but whether the level of circulating apoE4 protein in carriers affects cognition is unclear, as is how health and lifestyle impact circulating apoE4 levels.METHODS: We assayed apoE4 protein levels in dried blood spots of 12,532 adults aged 50+. Regression analyses tested the likelihood of cognitive impairment between groups and within those with detected apoE4 protein. Predictors of circulating apoE4 were assessed.RESULTS: We detected protein binding that indicates the presence of an APOE ε4 allele in 28.4% of this group. This group was more likely to have cognitive impairment, and this risk increases with age. However, higher apoE4 levels were associated with less likelihood of cognitive impairment within this group. Antihypertensive medication predicted apoE4 protein levels.DISCUSSION: The apoE4 isoform is associated with a deficient protein and worse cognition. This association is modulated by the level of circulating apoE4 protein in ε4 carriers. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

APOE ε4 allele
apoE4 protein
cognition
dried blood spots
SHARE

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