Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

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More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
androgen excess
developmental programming
genetic manipulation
therapeutic prevention
adipogenic constraint-induced lipotoxicity
naturally hyperandrogenic female monkeys
anti-mullerian hormone
prenatal testosterone excess
female
rhesus-monkeys
developmental programming impact
reproductive
neuroendocrine function
nerve growth-factor
low-dose
dihydrotestosterone
green fluorescent protein
receptor
gene-expression
genome-wide association
Endocrinology & Metabolism
adipogenic constraint-induced lipotoxicity
Translationell medicin TRIM

Padmanabhan, V.Departments of Pediatrics, Obstetrics and Gynecology, and Environmental Health Sciences, University of Michigan, Ann Arbor, USA (author)
Walters, K. A.Fertility & Research Centre, School of Women's and Children's Health, University of New South Wales, Sydney, Australia (author)
Campbell, R. E.Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand (author)
Benrick, Anna,1979Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine(Swepub:his)benb (author)
Giacobini, P.University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, France (author)
Dumesic, D. A.Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, USA (author)
Abbott, D. H.Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, USA (author)
Karolinska InstitutetDepartments of Pediatrics, Obstetrics and Gynecology, and Environmental Health Sciences, University of Michigan, Ann Arbor, USA (creator_code:org_t)

By the author/editor: Stener-Victorin, ...; Padmanabhan, V.; Walters, K. A.; Campbell, R. E.; Benrick, Anna, 1 ...; Giacobini, P.; show more...; Dumesic, D. A.; Abbott, D. H.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

By the university: University of Gothenburg; University of Skövde; Karolinska Institutet

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