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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

Stener-Victorin, E. (författare)
Karolinska Institutet
Padmanabhan, V. (författare)
Departments of Pediatrics, Obstetrics and Gynecology, and Environmental Health Sciences, University of Michigan, Ann Arbor, USA
Walters, K. A. (författare)
Fertility & Research Centre, School of Women's and Children's Health, University of New South Wales, Sydney, Australia
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Campbell, R. E. (författare)
Centre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Benrick, Anna, 1979 (författare)
Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine
Giacobini, P. (författare)
University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, France
Dumesic, D. A. (författare)
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, USA
Abbott, D. H. (författare)
Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, USA
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 (creator_code:org_t)
2020-04-20
2020
Engelska.
Ingår i: Endocrine Reviews. - : The Endocrine Society. - 0163-769X .- 1945-7189. ; 41:4
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

androgen excess
developmental programming
genetic manipulation
therapeutic prevention
adipogenic constraint-induced lipotoxicity
naturally hyperandrogenic female monkeys
anti-mullerian hormone
prenatal testosterone excess
female
rhesus-monkeys
developmental programming impact
reproductive
neuroendocrine function
nerve growth-factor
low-dose
dihydrotestosterone
green fluorescent protein
receptor
gene-expression
genome-wide association
Endocrinology & Metabolism
adipogenic constraint-induced lipotoxicity
Translationell medicin TRIM

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