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Inflammation-relate...
Inflammation-related plasma and CSF biomarkers for multiple sclerosis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-26
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Proceedings of the National Academy of Sciences,2020
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LIBRIS-ID:oai:gup.ub.gu.se/295070
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https://gup.ub.gu.se/publication/295070URI
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https://doi.org/10.1073/pnas.1912839117DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144128679URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Effective biomarkers for multiple sclerosis diagnosis, assessment of prognosis, and treatment responses, in particular those measur-able in blood, are largely lacking. We have investigated a broad set of protein biomarkers in cerebrospinal fluid (CSF) and plasma using a highly sensitive proteomic immunoassay. Cases from two independent cohorts were compared with healthy controls and patients with other neurological diseases. We identified and replicated 10 cerebrospinal fluid proteins including IL-12B, CD5, MIP-1a, and CXCL9 which had a combined diagnostic efficacy sim-ilar to immunoglobulin G (IgG) index and neurofilament light chain (area under the curve [AUC] = 0.95). Two plasma proteins, OSM and HGF, were also associated with multiple sclerosis in compari-son to healthy controls. Sensitivity and specificity of combined CSF and plasma markers for multiple sclerosis were 85.7% and 73.5%, respectively. In the discovery cohort, eotaxin-1 (CCL11) was asso-ciated with disease duration particularly in patients who had sec-ondary progressive disease (P-CSF < 4 x 10(-5) , P plasma < 4 x 10-5 ), and plasma CCL20 was associated with disease severity (P = 4 x 10(-5) ), although both require further validation. Treatment with natalizumab and fingolimod showed different compartmental changes in protein levels of CSF and peripheral blood, respectively, including many disease-associated markers (e.g., IL12B, CD5) showing potential application for both diagnosing disease and monitoring treatment efficacy. We report a number of multiple sclerosis biomarkers in CSF and plasma for early disease detection and potential indicators for disease activity. Of particular impor-tance is the set of markers discovered in blood, where validated biomarkers are lacking.
Subject headings and genre
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Khademi, M.Karolinska Institutet
(author)
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Fugger, L.
(author)
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Lindhe, O.
(author)
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Novakova, Lenka,1984Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xnovle
(author)
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Axelsson, Markus,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xaxmar
(author)
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Malmeström, Clas,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xmalcl
(author)
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Constantinescu, Clara,1995Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xconsc
(author)
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Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xlycja
(author)
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Piehl, F.Karolinska Institutet
(author)
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Olsson, T.Karolinska Institutet
(author)
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Kockum, I.Karolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
Related titles
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In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences117:23, s. 12952-129600027-84241091-6490
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In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences117:23, s. 12952-129601091-6490
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Huang, J.
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Khademi, M.
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Fugger, L.
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Lindhe, O.
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Novakova, Lenka, ...
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Axelsson, Markus ...
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Malmeström, Clas ...
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Constantinescu, ...
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Lycke, Jan, 1956
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Piehl, F.
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Olsson, T.
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Kockum, I.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Proceedings of t ...
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University of Gothenburg
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Karolinska Institutet