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Diffusion-Weighted ...
Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients-Neuroradiological Review Within the MRI-GENIE Study
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- Drake, Mattias (author)
- Lund University,Lunds universitet,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Frid, Petrea (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Hansen, Björn (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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Wu, O. (author)
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Giese, A. K. (author)
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Schirmer, M. D. (author)
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Donahue, K. (author)
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Cloonan, L. (author)
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Irie, R. E. (author)
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Bouts, Mjrj (author)
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McIntosh, E. C. (author)
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Mocking, S. J. T. (author)
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Dalca, A. V. (author)
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Sridharan, R. (author)
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Xu, H. C. (author)
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Giralt-Steinhauer, E. (author)
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- Holmegaard, Lukas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Roquer, J. (author)
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- Wasselius, Johan (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital
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McArdle, P. F. (author)
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Broderick, J. P. (author)
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Jimenez-Conde, J. (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Kissela, B. M. (author)
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Kleindorfer, D. O. (author)
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Lemmens, R. (author)
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Meschia, J. F. (author)
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Rundek, T. (author)
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Sacco, R. L. (author)
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Schmidt, R. (author)
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Sharma, P. (author)
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Slowik, A. (author)
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Thijs, V. (author)
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Woo, D. (author)
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Worrall, B. B. (author)
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Kittner, S. J. (author)
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Mitchell, B. D. (author)
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Rosand, J. (author)
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Golland, P. (author)
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- Lindgren, Arne (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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Rost, N. S. (author)
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Wasselius, J. (author)
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(creator_code:org_t)
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- 2020-06-25
- 2020
- English.
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In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 11
- Related links:
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https://www.frontier...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background:Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work. Methods:The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N= 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics. Results:In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P= 0.013 for chi(2)test). Conclusions:This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- stroke
- imaging
- MRI
- phenotype
- DWI
- brain
- circulation
- design
- ct
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Drake, Mattias
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Frid, Petrea
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Hansen, Björn
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Wu, O.
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Giese, A. K.
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Schirmer, M. D.
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show more...
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Donahue, K.
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Cloonan, L.
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Irie, R. E.
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Bouts, Mjrj
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McIntosh, E. C.
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Mocking, S. J. T ...
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Dalca, A. V.
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Sridharan, R.
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Xu, H. C.
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Giralt-Steinhaue ...
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Holmegaard, Luka ...
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Jood, Katarina, ...
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Roquer, J.
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Wasselius, Johan
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McArdle, P. F.
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Broderick, J. P.
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Jimenez-Conde, J ...
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Jern, Christina, ...
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Kissela, B. M.
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Kleindorfer, D. ...
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Lemmens, R.
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Meschia, J. F.
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Rundek, T.
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Sacco, R. L.
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Schmidt, R.
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Sharma, P.
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Slowik, A.
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Thijs, V.
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Woo, D.
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Worrall, B. B.
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Kittner, S. J.
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Mitchell, B. D.
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Rosand, J.
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Golland, P.
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Lindgren, Arne
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Rost, N. S.
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Wasselius, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Frontiers in Neu ...
- By the university
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University of Gothenburg
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Lund University