Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke

Cognitive impairment is common after stroke, and disturbances in hippocampal function are often involved, even in remote non-hippocampal injuries. In terms of hippocampal function, growth hormone (GH) is known to affects plasticity and cognition. We aimed to investigate whether GH treatment after an experimental cortical stroke could enhance remote hippocampal plasticity and the hippocampal-dependent visual discrimination task. C57BL6 male mice were subjected to cortical photothrombotic stroke. Stroke mice were then treated with either saline or GH at 48 h after occlusion for 28 days. We assessed learning and memory using mouse touchscreen platform for the visual discrimination task. We also evaluated markers of neural progenitor cells, synaptic plasticity and cerebrovascular remodelling in the hippocampal formation. GH treatment significantly improved the performance on visual discrimination task after stroke. We observed a concomitant increased number of bromodeoxyuridine-positive cells in the dentate gyrus of the hippocampus. We also detected increased protein levels and density of doublecortin, a neuronal precursor cells marker, as well as glutamate receptor 1 (GLuR1), a synaptic marker. These findings provide further neurobiological evidence for how GH treatment could be used to promote hippocampal plasticity in a remote region from the initial cortical injury, and thus enhance cognitive recovery after stroke.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
cognition
growth hormone
hippocampus
neurogenesis
synaptic
plasticity
visual discrimination
transient global-ischemia
amyloid-beta accumulation
neural stem-cells
i gene-expression
secondary neurodegeneration
dentate gyrus
forebrain
neurogenesis
brain
gh
poststroke
Biochemistry & Molecular Biology
Chemistry

Åberg, N David,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xabeda (författare)
Crock, P. (författare)
Walker, F. R. (författare)
Nilsson, M. (författare)
Isgaard, Jörgen,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xisgjo (författare)
Ong, L. K. (författare)
Göteborgs universitetInstitutionen för medicin (creator_code:org_t)

Av författaren/redakt...: Sanchez-Bezanill ...; Åberg, N David, ...; Crock, P.; Walker, F. R.; Nilsson, M.; Isgaard, Jörgen, ...; visa fler...; Ong, L. K.; visa färre...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.