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Parents' smoking on...
Parents' smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study
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- Knudsen, G. T. M. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
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- Dharmage, S. (författare)
- Univ Melbourne, Sch Populat & Global Hlth, Carlton, Vic, Australia.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Abramson, M. J. (författare)
- Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
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- Benediktsdottir, B. (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali, Dept Sleep Med, Reykjavik, Iceland.
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Skulstad, S. M. (författare)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
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- Bertelsen, R. J. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Oral Hlth Ctr Expertise Western Norway, Bergen, Norway.
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- Real, F. G. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.
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- Schlunssen, V. (författare)
- Aarhus Univ, Dept Publ Hlth Work Environm & Hlth, Danish Ramazzini Ctr, Aarhus, Denmark.;Natl Res Ctr Working Environm, Copenhagen, Denmark.
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- Jogi, N. O. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
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- Sanchez-Ramos, J. L. (författare)
- Huelva Univ, Dept Nursing, Huelva, Spain.
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- Holm, Mathias, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Occupat & Environm Med, Sch Publ Hlth & Community Med, Inst Med, Gothenburg, Sweden.
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- Garcia-Aymerich, J. (författare)
- ISGlobal, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
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- Forsberg, Bertil (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
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- Svanes, C. (författare)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
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- Johannessen, A. (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
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Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway. Univ Melbourne, Sch Populat & Global Hlth, Carlton, Vic, Australia. (creator_code:org_t)
- 2020-07-06
- 2020
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 15:7
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Emerging evidence suggests that parents' preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index (BMI) and fat mass index (FMI). We investigated fathers (n = 2111) and mothers (n = 2569) aged 39-65 years, of the population based RHINE and ECRHS studies, and their offspring aged 18-49 years (n = 6487, mean age 29.6 years) who participated in the RHINESSA study. BMI was calculated from self-reported height and weight, and FMI was estimated from bioelectrical impedance measures in a subsample. Associations with parental smoking were analysed with generalized linear regression adjusting for parental education and clustering by study centre and family. Interactions between offspring sex were analysed, as was mediation by parental pack years, parental BMI, offspring smoking and offspring birthweight. Fathers' smoking onset before conception of the offspring (onset >= 15 years) was associated with higher BMI in the offspring when adult (beta 0.551, 95%CI: 0.174-0.929, p = 0.004). Mothers' preconception and postnatal smoking onset was associated with higher offspring BMI (onset <15 years: beta 1.161, 95%CI 0.378-1.944; onset >= 15 years: beta 0.720, 95%CI 0.293-1.147; onset after offspring birth: beta 2.257, 95%CI 1.220-3.294). However, mediation analysis indicated that these effects were fully mediated by parents' postnatal pack years, and partially mediated by parents' BMI and offspring smoking. Regarding FMI, sons of smoking fathers also had higher fat mass (onset <15 years beta 1.604, 95%CI 0.269-2.939; onset >= 15 years beta 2.590, 95%CI 0.544-4.636; and onset after birth beta 2.736, 95%CI 0.621-4.851). There was no association between maternal smoking and offspring fat mass. We found that parents' smoking before conception was associated with higher BMI in offspring when they reached adulthood, but that these effects were mediated through parents' pack years, suggesting that cumulative smoking exposure during offspring's childhood may elicit long lasting effects on offspring BMI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- Av författaren/redakt...
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Knudsen, G. T. M ...
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Dharmage, S.
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Janson, Christer
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Abramson, M. J.
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Benediktsdottir, ...
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Malinovschi, And ...
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visa fler...
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Skulstad, S. M.
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Bertelsen, R. J.
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Real, F. G.
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Schlunssen, V.
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Jogi, N. O.
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Sanchez-Ramos, J ...
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Holm, Mathias, 1 ...
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Garcia-Aymerich, ...
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Forsberg, Bertil
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Svanes, C.
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Johannessen, A.
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