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  • Attarbaschi, A. (author)

Second malignant neoplasms after treatment of non-Hodgkin’s lymphoma—a retrospective multinational study of 189 children and adolescents

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-05-11
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/296102
  • https://gup.ub.gu.se/publication/296102URI
  • https://doi.org/10.1038/s41375-020-0841-xDOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Data on the spectrum of second malignant neoplasms (SMNs) after primary childhood non-Hodgkin’s lymphoma (NHL) are scarce. One-hundred-and-eighty-nine NHL patients diagnosed in a 30 years period of 1980–2010 developing an SMN were retrieved from 19 members of the European Intergroup for Childhood NHL and/or the international Berlin-Frankfurt-Münster Study Group. Five subgroups of SMNs were identified: (1) myeloid neoplasms (n = 43; 23%), (2) lymphoid neoplasms (n = 51; 27%), (3) carcinomas (n = 48; 25%), (4) central nervous system (CNS) tumors (n = 19; 10%), and (5) “other” SMNs (n = 28; 15%). In 37 patients (20%) preexisting disorders were reported with 90% having any kind of cancer predisposition syndrome (CPS). For the 189 primary NHL patients, 5-year overall survival (OS) after diagnosis of an SMN was 56 ± 4%, being worst for patients with preexisting disorders at 28 ± 8%. Five-year OS rates were 38 ± 8%, 59 ± 7%, 79 ± 8%, 34 ± 12%, and 62 ± 11%, respectively, for patients with myeloid and lymphoid neoplasms, carcinomas, CNS tumors, and “other” SMNs (p < 0.0001). Patients with SMNs after childhood NHL having a reported CPS, mostly mismatch repair disorders, carried a very poor prognosis. Moreover, although outcome was favorable in some subtypes of SMNs after childhood NHL (carcinomas, lymphoid neoplasms), other SMNs such as myeloid neoplasms and CNS tumors had a dismal prognosis. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carraro, E. (author)
  • Ronceray, L. (author)
  • Andrés, M. (author)
  • Barzilai-Birenboim, S. (author)
  • Bomken, S. (author)
  • Brugières, L. (author)
  • Burkhardt, B. (author)
  • Ceppi, F. (author)
  • Chiang, A. K. S. (author)
  • Csoka, M. (author)
  • Fedorova, A. (author)
  • Jazbec, J. (author)
  • Kabickova, E. (author)
  • Loeffen, J. (author)
  • Mellgren, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xmellk (author)
  • Miakova, N. (author)
  • Moser, O. (author)
  • Osumi, T. (author)
  • Pourtsidis, A. (author)
  • Rigaud, C. (author)
  • Uyttebroeck, A. (author)
  • Woessmann, W. (author)
  • Pillon, M. (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

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