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Genetic identificat...
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
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- Bryois, J. (author)
- Karolinska Institutet
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Skene, N. G. (author)
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Hansen, T. F. (author)
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show more...
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Kogelman, L. J. A. (author)
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Watson, H. J. (author)
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Liu, Z. (author)
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- Adan, Roger A. H. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Alfredsson, L. (author)
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Ando, T. (author)
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Andreassen, O. (author)
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Baker, J. (author)
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Bergen, A. (author)
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Berrettini, W. (author)
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Birgegård, A. (author)
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Boden, J. (author)
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Boehm, I. (author)
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Boni, C. (author)
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Boraska Perica, V. (author)
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Brandt, H. (author)
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Breen, G. (author)
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Bryois, J. (author)
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Buehren, K. (author)
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Bulik, C. (author)
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Burghardt, R. (author)
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Cassina, M. (author)
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Cichon, S. (author)
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Clementi, M. (author)
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Coleman, J. (author)
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Cone, R. (author)
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Courtet, P. (author)
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Crawford, S. (author)
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Crow, S. (author)
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Crowley, J. (author)
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Danner, U. (author)
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Davis, O. (author)
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de Zwaan, M. (author)
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Dedoussis, G. (author)
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Degortes, D. (author)
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DeSocio, J. (author)
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Dick, D. (author)
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Dikeos, D. (author)
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Dina, C. (author)
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Dmitrzak-Weglarz, M. (author)
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Docampo Martinez, E. (author)
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Duncan, L. (author)
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Egberts, K. (author)
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Ehrlich, S. (author)
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Escaramís, G. (author)
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Esko, T. (author)
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Estivill, X. (author)
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Farmer, A. (author)
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Favaro, A. (author)
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Fernández-Aranda, F. (author)
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Fichter, M. (author)
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Fischer, K. (author)
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Föcker, M. (author)
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Foretova, L. (author)
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Forstner, A. (author)
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Forzan, M. (author)
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Franklin, C. (author)
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Gallinger, S. (author)
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Gaspar, H. (author)
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Giegling, I. (author)
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Giuranna, J. (author)
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Giusti-Rodríquez, P. (author)
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Gonidakis, F. (author)
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Gordon, S. (author)
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Gorwood, P. (author)
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Gratacos Mayora, M. (author)
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Grove, J. (author)
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Guillaume, S. (author)
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Guo, Y. (author)
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Hakonarson, H. (author)
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Halmi, K. (author)
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Hanscombe, K. (author)
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Hatzikotoulas, K. (author)
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Hauser, J. (author)
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Hebebrand, J. (author)
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Helder, S. (author)
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Henders, A. (author)
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Herms, S. (author)
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Herpertz-Dahlmann, B. (author)
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Herzog, W. (author)
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Hinney, A. (author)
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Horwood, L. J. (author)
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Hübel, C. (author)
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Huckins, L. (author)
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Hudson, J. (author)
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Imgart, H. (author)
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Inoko, H. (author)
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Janout, V. (author)
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Jiménez-Murcia, S. (author)
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Johnson, C. (author)
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Jordan, J. (author)
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Julià, A. (author)
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Juréus, A. (author)
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Kalsi, G. (author)
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Kaminská, D. (author)
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Kaplan, A. (author)
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Kaprio, J. (author)
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Karhunen, L. (author)
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Karwautz, A. (author)
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Kas, M. (author)
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Kaye, W. (author)
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Kennedy, J. (author)
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Kennedy, M. (author)
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Keski-Rahkonen, A. (author)
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Kiezebrink, K. (author)
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Kim, Y. R. (author)
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Kirk, K. (author)
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Klareskog, L. (author)
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Klump, K. (author)
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Knudsen, G. P. (author)
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La Via, M. (author)
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Landén, M. (author)
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Larsen, J. (author)
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Le Hellard, S. (author)
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Leppä, V. (author)
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Levitan, R. (author)
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Li, D. (author)
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Lichtenstein, P. (author)
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Lilenfeld, L. (author)
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Lin, B. D. (author)
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Lissowska, J. (author)
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Luykx, J. (author)
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Magistretti, P. (author)
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Maj, M. (author)
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Mannik, K. (author)
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Marsal, S. (author)
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Marshall, C. (author)
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Martin, N. (author)
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Mattheisen, M. (author)
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Mattingsdal, M. (author)
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McDevitt, S. (author)
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McGuffin, P. (author)
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Medland, S. (author)
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Metspalu, A. (author)
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Meulenbelt, I. (author)
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Micali, N. (author)
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Mitchell, J. (author)
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Mitchell, K. (author)
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Monteleone, P. (author)
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Monteleone, A. M. (author)
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Montgomery, G. (author)
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Mortensen, P. B. (author)
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Munn-Chernoff, M. (author)
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Nacmias, B. (author)
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Navratilova, M. (author)
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Norring, C. (author)
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Ntalla, I. (author)
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Olsen, C. (author)
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Ophoff, R. (author)
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O’Toole, J. (author)
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Padyukov, L. (author)
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Palotie, A. (author)
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Pantel, J. (author)
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Papezova, H. (author)
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Parker, R. (author)
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Pearson, J. (author)
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Pedersen, N. (author)
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Petersen, L. (author)
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Pinto, D. (author)
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Purves, K. (author)
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Rabionet, R. (author)
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Raevuori, A. (author)
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Ramoz, N. (author)
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Reichborn-Kjennerud, T. (author)
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Ricca, V. (author)
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Ripatti, S. (author)
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Ripke, S. (author)
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Ritschel, F. (author)
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Roberts, M. (author)
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Rotondo, A. (author)
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Rujescu, D. (author)
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Rybakowski, F. (author)
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Santonastaso, P. (author)
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Scherag, A. (author)
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Scherer, S. (author)
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Schmidt, U. (author)
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Schork, N. (author)
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Schosser, A. (author)
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Seitz, J. (author)
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Slachtova, L. (author)
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Slagboom, P. E. (author)
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Slof-Op ‘t Landt, M. (author)
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Slopien, A. (author)
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Sorbi, S. (author)
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Strober, M. (author)
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Stuber, G. (author)
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Sullivan, P. (author)
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Świątkowska, B. (author)
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Szatkiewicz, J. (author)
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Tachmazidou, I. (author)
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Tenconi, E. (author)
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Thornton, L. (author)
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Tortorella, A. (author)
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Tozzi, F. (author)
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Treasure, J. (author)
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Tsitsika, A. (author)
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Tyszkiewicz-Nwafor, M. (author)
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Tziouvas, K. (author)
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van Elburg, A. (author)
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van Furth, E. (author)
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Wade, T. (author)
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Wagner, G. (author)
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Walton, E. (author)
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Watson, H. (author)
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Werge, T. (author)
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Whiteman, D. (author)
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Widen, E. (author)
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Woodside, D. B. (author)
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Yao, S. (author)
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Yilmaz, Z. (author)
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Zeggini, E. (author)
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Zerwas, S. (author)
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Zipfel, S. (author)
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Anttila, V. (author)
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Artto, V. (author)
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Belin, A. C. (author)
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de Boer, I. (author)
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Boomsma, D. I. (author)
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Børte, S. (author)
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Chasman, D. I. (author)
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Cherkas, L. (author)
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Christensen, A. F. (author)
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Cormand, B. (author)
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Cuenca-Leon, E. (author)
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Davey-Smith, G. (author)
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Dichgans, M. (author)
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van Duijn, C. (author)
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Esko, T. (author)
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Esserlind, A. L. (author)
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Ferrari, M. (author)
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Frants, R. R. (author)
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Freilinger, T. (author)
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Furlotte, N. (author)
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Gormley, P. (author)
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Griffiths, L. (author)
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Hamalainen, E. (author)
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Hansen, T. F. (author)
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Hiekkala, M. (author)
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Ikram, M. A. (author)
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Ingason, A. (author)
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Järvelin, M. R. (author)
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Kajanne, R. (author)
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Kallela, M. (author)
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Kaprio, J. (author)
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Kaunisto, M. (author)
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Kogelman, L. J. A. (author)
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Kubisch, C. (author)
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Kurki, M. (author)
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Kurth, T. (author)
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Launer, L. (author)
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Lehtimaki, T. (author)
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Lessel, D. (author)
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Ligthart, L. (author)
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Litterman, N. (author)
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Maagdenberg, A. (author)
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Macaya, A. (author)
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Malik, R. (author)
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Mangino, M. (author)
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McMahon, G. (author)
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Muller-Myhsok, B. (author)
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Neale, B. M. (author)
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Northover, C. (author)
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Nyholt, D. R. (author)
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Olesen, J. (author)
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Palotie, A. (author)
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Palta, P. (author)
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Pedersen, L. (author)
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Pedersen, N. (author)
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Posthuma, D. (author)
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Pozo-Rosich, P. (author)
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Pressman, A. (author)
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Raitakari, O. (author)
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Schürks, M. (author)
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Sintas, C. (author)
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Stefansson, K. (author)
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Stefansson, H. (author)
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Steinberg, S. (author)
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Strachan, D. (author)
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Terwindt, G. (author)
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Vila-Pueyo, M. (author)
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Wessman, M. (author)
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Winsvold, B. S. (author)
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Zhao, H. (author)
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Zwart, J. A. (author)
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Agee, M. (author)
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Alipanahi, B. (author)
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Auton, A. (author)
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Bell, R. (author)
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Bryc, K. (author)
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Elson, S. (author)
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Fontanillas, P. (author)
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Furlotte, N. (author)
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Heilbron, K. (author)
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Hinds, D. (author)
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Huber, K. (author)
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Kleinman, A. (author)
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Litterman, N. (author)
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McCreight, J. (author)
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McIntyre, M. (author)
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Mountain, J. (author)
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Noblin, E. (author)
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Northover, C. (author)
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Pitts, S. (author)
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Sathirapongsasuti, J. (author)
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Sazonova, O. (author)
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Shelton, J. (author)
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Shringarpure, S. (author)
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Tian, C. (author)
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Tung, J. (author)
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Vacic, V. (author)
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Wilson, C. (author)
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Brueggeman, L. (author)
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Breen, G. (author)
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Bulik, C. M. (author)
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Arenas, E. (author)
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Hjerling-Leffler, J. (author)
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Sullivan, P. F. (author)
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(creator_code:org_t)
- 2020-04-27
- 2020
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493
- Related links:
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https://pure.rug.nl/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- hemoglobin A1c
- RNA
- Article
- autism
- bipolar disorder
- body mass
- cells by body anatomy
- cerebrovascular accident
- cholinergic nerve cell
- coronary artery disease
- disease exacerbation
- educational status
- gene expression
- genetic association
- genetic correlation
- genetic identification
- genome-wide association study
- glycemic control
- human
- human tissue
- inflammatory bowel disease
- mental disease
- monoamine nerve cell
- neurologic disease
- neurosis
- non insulin dependent diabetes mellitus
- nonhuman
- oligodendroglia
- Parkinson disease
- parkinsonism
- priority journal
- RNA sequencing
- schizophrenia
- single cell RNA seq
- transcriptomics
- upregulation
- waist hip ratio
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bryois, J.
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Skene, N. G.
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Hansen, T. F.
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Kogelman, L. J. ...
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Watson, H. J.
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Liu, Z.
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show more...
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Adan, Roger A. H ...
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Alfredsson, L.
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Ando, T.
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Andreassen, O.
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Baker, J.
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Bergen, A.
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Berrettini, W.
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Birgegård, A.
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Boden, J.
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Boehm, I.
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Boni, C.
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Boraska Perica, ...
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Brandt, H.
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Breen, G.
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Buehren, K.
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Bulik, C.
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Burghardt, R.
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Cassina, M.
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Cichon, S.
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Clementi, M.
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Coleman, J.
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Cone, R.
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Courtet, P.
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Crawford, S.
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Crow, S.
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Crowley, J.
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Danner, U.
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Davis, O.
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de Zwaan, M.
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Dedoussis, G.
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Degortes, D.
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DeSocio, J.
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Dick, D.
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Dikeos, D.
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Dina, C.
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Dmitrzak-Weglarz ...
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Docampo Martinez ...
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Duncan, L.
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Egberts, K.
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Ehrlich, S.
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Escaramís, G.
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Esko, T.
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Estivill, X.
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Farmer, A.
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Favaro, A.
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Fernández-Aranda ...
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Fichter, M.
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Fischer, K.
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Föcker, M.
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Foretova, L.
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Forstner, A.
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Forzan, M.
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Franklin, C.
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Gallinger, S.
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Gaspar, H.
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Giegling, I.
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Giuranna, J.
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Giusti-Rodríquez ...
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Gonidakis, F.
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Gordon, S.
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Gorwood, P.
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Gratacos Mayora, ...
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Grove, J.
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Guillaume, S.
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Guo, Y.
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Hakonarson, H.
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Halmi, K.
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Hanscombe, K.
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Hatzikotoulas, K ...
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Hauser, J.
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Hebebrand, J.
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Helder, S.
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Henders, A.
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Herms, S.
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Herpertz-Dahlman ...
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Herzog, W.
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Hinney, A.
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Horwood, L. J.
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Hübel, C.
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Huckins, L.
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Hudson, J.
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Imgart, H.
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Inoko, H.
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Janout, V.
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Jiménez-Murcia, ...
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Johnson, C.
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Jordan, J.
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Julià, A.
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Juréus, A.
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Kalsi, G.
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Kaminská, D.
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Kaplan, A.
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Kaprio, J.
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Karhunen, L.
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Karwautz, A.
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Kas, M.
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Kaye, W.
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Kennedy, J.
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Kennedy, M.
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Keski-Rahkonen, ...
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Kiezebrink, K.
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Kim, Y. R.
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Kirk, K.
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Klareskog, L.
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Klump, K.
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Knudsen, G. P.
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La Via, M.
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Landén, M.
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Larsen, J.
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Le Hellard, S.
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Leppä, V.
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Levitan, R.
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Li, D.
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Lichtenstein, P.
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Lilenfeld, L.
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Lin, B. D.
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Lissowska, J.
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Luykx, J.
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Magistretti, P.
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Maj, M.
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Mannik, K.
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Marsal, S.
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Marshall, C.
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Martin, N.
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Mattheisen, M.
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Mattingsdal, M.
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McDevitt, S.
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McGuffin, P.
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Medland, S.
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Metspalu, A.
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Meulenbelt, I.
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Micali, N.
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Mitchell, J.
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Mitchell, K.
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Monteleone, P.
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Monteleone, A. M ...
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Montgomery, G.
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Mortensen, P. B.
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Munn-Chernoff, M ...
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Nacmias, B.
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Navratilova, M.
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Norring, C.
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Ntalla, I.
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Olsen, C.
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Ophoff, R.
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O’Toole, J.
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Padyukov, L.
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Palotie, A.
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Pantel, J.
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Papezova, H.
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Parker, R.
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Pearson, J.
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Pedersen, N.
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Petersen, L.
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Pinto, D.
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Purves, K.
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Rabionet, R.
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Raevuori, A.
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Ramoz, N.
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Reichborn-Kjenne ...
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Ricca, V.
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Ripatti, S.
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Ripke, S.
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Ritschel, F.
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Roberts, M.
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Rotondo, A.
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Rujescu, D.
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Rybakowski, F.
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Santonastaso, P.
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Scherag, A.
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Scherer, S.
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Schmidt, U.
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Schork, N.
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Schosser, A.
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Seitz, J.
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Slachtova, L.
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Slagboom, P. E.
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Slof-Op ‘t Landt ...
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Slopien, A.
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Sorbi, S.
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Strober, M.
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Stuber, G.
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Sullivan, P.
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Świątkowska, B.
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Szatkiewicz, J.
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Tachmazidou, I.
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Tenconi, E.
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Thornton, L.
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Tortorella, A.
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Tozzi, F.
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Treasure, J.
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Tyszkiewicz-Nwaf ...
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Tziouvas, K.
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van Elburg, A.
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van Furth, E.
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Wade, T.
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Wagner, G.
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Walton, E.
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Watson, H.
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Werge, T.
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Whiteman, D.
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Widen, E.
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Woodside, D. B.
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Yao, S.
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Yilmaz, Z.
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Zeggini, E.
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Zerwas, S.
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Zipfel, S.
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Anttila, V.
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Artto, V.
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Belin, A. C.
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de Boer, I.
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Boomsma, D. I.
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Børte, S.
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Chasman, D. I.
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Cherkas, L.
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Christensen, A. ...
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Cormand, B.
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Cuenca-Leon, E.
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Davey-Smith, G.
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Dichgans, M.
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van Duijn, C.
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Esserlind, A. L.
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Ferrari, M.
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Frants, R. R.
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Freilinger, T.
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Furlotte, N.
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Gormley, P.
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Griffiths, L.
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Hamalainen, E.
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Hiekkala, M.
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Ikram, M. A.
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Ingason, A.
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Järvelin, M. R.
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Kajanne, R.
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Kallela, M.
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Kaunisto, M.
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Kubisch, C.
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Kurki, M.
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Kurth, T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Genetics
- By the university
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University of Gothenburg
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Karolinska Institutet