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  • Cherubini, V.Salesi Hosp, Italy (author)

Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-05-08
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/296173
  • https://gup.ub.gu.se/publication/296173URI
  • https://doi.org/10.1007/s00125-020-05152-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166185URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Projekt DEAL
  • Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results: During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation: DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups. © 2020, The Author(s).

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Grimsmann, J. M.Univ Ulm, Germany; German Ctr Diabet Res DZD, Germany (author)
  • Åkesson, KarinLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Ryhov Cty Hosp, Sweden(Swepub:liu)karak14 (author)
  • Birkebæk, N. H.Aarhus Univ Hosp, Denmark (author)
  • Cinek, O.Charles Univ Prague, Czech Republic; Motol Univ Hosp, Czech Republic (author)
  • Dovč, K.UMC Univ Childrens Hosp, Slovenia; Fac Med, Slovenia (author)
  • Gesuita, R.Polytech Univ Marche, Italy (author)
  • Gregory, J. W.Cardiff Univ, Wales (author)
  • Hanås, Ragnar,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,NU Hosp Grp, Sweden; Gothenburg Univ, Sweden(Swepub:gu)xhanra (author)
  • Hofer, S. E.Med Univ Innsbruck, Austria (author)
  • Holl, R. W.Univ Ulm, Germany; German Ctr Diabet Res DZD, Germany (author)
  • Jefferies, C.Starship Childrens Hlth, New Zealand (author)
  • Joner, G.Oslo Univ Hosp, Norway; Univ Oslo, Norway (author)
  • King, B. R.Univ Newcastle, Australia (author)
  • Mayer-Davis, E. J.Univ N Carolina, NC 27515 USA (author)
  • Peña, A. S.Univ Adelaide, Australia (author)
  • Rami-Merhar, B.Med Univ Vienna, Austria (author)
  • Schierloh, U.Ctr Hosp, Luxembourg (author)
  • Skrivarhaug, T.Oslo Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Sumnik, Z.Charles Univ Prague, Czech Republic; Motol Univ Hosp, Czech Republic (author)
  • Svensson, J.Copenhagen Univ Hosp, Denmark (author)
  • Warner, J. T.Univ Hosp Wales, Wales (author)
  • Bratina, N.UMC Univ Childrens Hosp, Slovenia; Fac Med, Slovenia (author)
  • Dabelea, D.Univ Colorado, CO USA (author)
  • Salesi Hosp, ItalyUniv Ulm, Germany; German Ctr Diabet Res DZD, Germany (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC63, s. 1530-15410012-186X1432-0428

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