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White matter hyperi...
White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype
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Giese, A. K. (author)
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Schirmer, M. D. (author)
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Dalca, A. V. (author)
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show more...
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Sridharan, R. (author)
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Donahue, K. L. (author)
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Nardin, M. (author)
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Irie, R. (author)
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McIntosh, E. C. (author)
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Mocking, S. J. T. (author)
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Xu, H. C. (author)
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Cole, J. W. (author)
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Giralt-Steinhauer, E. (author)
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Jimenez-Conde, J. (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Kleindorfer, D. O. (author)
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Lemmens, R. (author)
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Wasselius, J. (author)
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Lindgren, A. (author)
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Rundek, T. (author)
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Sacco, R. L. (author)
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Schmidt, R. (author)
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Sharma, P. (author)
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Slowik, A. (author)
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Thijs, V. (author)
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Worrall, B. B. (author)
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Woo, D. (author)
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Kittner, S. J. (author)
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McArdle, P. F. (author)
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Mitchell, B. D. (author)
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Rosand, J. (author)
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Meschia, J. F. (author)
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Wu, O. (author)
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Golland, P. (author)
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Rost, N. S. (author)
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Int Stroke Genet, Consortium (author)
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Mri-Genie Investigators, Mri-Genie Investigators (author)
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(creator_code:org_t)
- 2020-06-03
- 2020
- English.
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In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 95:1
- Related links:
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https://www.ncbi.nlm...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- ObjectiveTo examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS).MethodsFor the MRI Genetics Interface Exploration (MRI-GENIE) study, we systematically assembled brain imaging and phenotypic data for 3,301 patients with AIS. All cases underwent standardized web tool-based stroke subtyping with the Causative Classification of Ischemic Stroke (CCS). WMH volume (WMHv) was measured on T2 brain MRI scans of 2,529 patients with a fully automated deep-learning trained algorithm. Univariable and multivariable linear mixed-effects modeling was carried out to investigate the relationship of vascular risk factors with WMHv and CCS subtypes.ResultsPatients with AIS with large artery atherosclerosis, major cardioembolic stroke, small artery occlusion (SAO), other, and undetermined causes of AIS differed significantly in their vascular risk factor profile (all p < 0.001). Median WMHv in all patients with AIS was 5.86 cm(3) (interquartile range 2.18-14.61 cm(3)) and differed significantly across CCS subtypes (p < 0.0001). In multivariable analysis, age, hypertension, prior stroke, smoking (all p < 0.001), and diabetes mellitus (p = 0.041) were independent predictors of WMHv. When adjusted for confounders, patients with SAO had significantly higher WMHv compared to those with all other stroke subtypes (p < 0.001).ConclusionIn this international multicenter, hospital-based cohort of patients with AIS, we demonstrate that vascular risk factor profiles and extent of WMH burden differ by CCS subtype, with the highest lesion burden detected in patients with SAO. These findings further support the small vessel hypothesis of WMH lesions detected on brain MRI of patients with ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- genome-wide association
- genetics network sign
- causative
- classification
- leukoaraiosis
- determinants
- lesions
- volume
- risk
- outcomes
- mri
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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To the university's database
- By the author/editor
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Giese, A. K.
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Schirmer, M. D.
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Dalca, A. V.
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Sridharan, R.
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Donahue, K. L.
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Nardin, M.
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show more...
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Irie, R.
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McIntosh, E. C.
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Mocking, S. J. T ...
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Xu, H. C.
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Cole, J. W.
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Giralt-Steinhaue ...
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Jimenez-Conde, J ...
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Jern, Christina, ...
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Kleindorfer, D. ...
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Lemmens, R.
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Wasselius, J.
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Lindgren, A.
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Rundek, T.
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Sacco, R. L.
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Schmidt, R.
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Sharma, P.
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Slowik, A.
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Thijs, V.
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Worrall, B. B.
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Woo, D.
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Kittner, S. J.
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McArdle, P. F.
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Mitchell, B. D.
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Rosand, J.
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Meschia, J. F.
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Wu, O.
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Golland, P.
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Rost, N. S.
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Int Stroke Genet ...
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Mri-Genie Invest ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg