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  • Giese, A. K. (author)

White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-06-03
  • Ovid Technologies (Wolters Kluwer Health),2020

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/296229
  • https://gup.ub.gu.se/publication/296229URI
  • https://doi.org/10.1212/wnl.0000000000009728DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • ObjectiveTo examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS).MethodsFor the MRI Genetics Interface Exploration (MRI-GENIE) study, we systematically assembled brain imaging and phenotypic data for 3,301 patients with AIS. All cases underwent standardized web tool-based stroke subtyping with the Causative Classification of Ischemic Stroke (CCS). WMH volume (WMHv) was measured on T2 brain MRI scans of 2,529 patients with a fully automated deep-learning trained algorithm. Univariable and multivariable linear mixed-effects modeling was carried out to investigate the relationship of vascular risk factors with WMHv and CCS subtypes.ResultsPatients with AIS with large artery atherosclerosis, major cardioembolic stroke, small artery occlusion (SAO), other, and undetermined causes of AIS differed significantly in their vascular risk factor profile (all p < 0.001). Median WMHv in all patients with AIS was 5.86 cm(3) (interquartile range 2.18-14.61 cm(3)) and differed significantly across CCS subtypes (p < 0.0001). In multivariable analysis, age, hypertension, prior stroke, smoking (all p < 0.001), and diabetes mellitus (p = 0.041) were independent predictors of WMHv. When adjusted for confounders, patients with SAO had significantly higher WMHv compared to those with all other stroke subtypes (p < 0.001).ConclusionIn this international multicenter, hospital-based cohort of patients with AIS, we demonstrate that vascular risk factor profiles and extent of WMH burden differ by CCS subtype, with the highest lesion burden detected in patients with SAO. These findings further support the small vessel hypothesis of WMH lesions detected on brain MRI of patients with ischemic stroke.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Schirmer, M. D. (author)
  • Dalca, A. V. (author)
  • Sridharan, R. (author)
  • Donahue, K. L. (author)
  • Nardin, M. (author)
  • Irie, R. (author)
  • McIntosh, E. C. (author)
  • Mocking, S. J. T. (author)
  • Xu, H. C. (author)
  • Cole, J. W. (author)
  • Giralt-Steinhauer, E. (author)
  • Jimenez-Conde, J. (author)
  • Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xjerch (author)
  • Kleindorfer, D. O. (author)
  • Lemmens, R. (author)
  • Wasselius, J. (author)
  • Lindgren, A. (author)
  • Rundek, T. (author)
  • Sacco, R. L. (author)
  • Schmidt, R. (author)
  • Sharma, P. (author)
  • Slowik, A. (author)
  • Thijs, V. (author)
  • Worrall, B. B. (author)
  • Woo, D. (author)
  • Kittner, S. J. (author)
  • McArdle, P. F. (author)
  • Mitchell, B. D. (author)
  • Rosand, J. (author)
  • Meschia, J. F. (author)
  • Wu, O. (author)
  • Golland, P. (author)
  • Rost, N. S. (author)
  • Int Stroke Genet, Consortium (author)
  • Mri-Genie Investigators, Mri-Genie Investigators (author)
  • Göteborgs universitetInstitutionen för biomedicin (creator_code:org_t)

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  • In:Neurology: Ovid Technologies (Wolters Kluwer Health)95:10028-38781526-632X

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