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  • van Lier, Y. F. (author)

Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2020

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  • LIBRIS-ID:oai:gup.ub.gu.se/296463
  • https://gup.ub.gu.se/publication/296463URI
  • https://doi.org/10.1126/scitranslmed.aaz8926DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Disruption of the intestinal microbiota occurs frequently in allogeneic hematopoietic cell transplantation (allo-HCT) recipients and predisposes them to development of graft-versus-host disease (GvHD). In a prospective, single-center, single-arm study, we investigated the effect of donor fecal microbiota transplantation (FMT) on symptoms of steroid-refractory or steroid-dependent, acute or late-onset acute intestinal GvHD in 15 individuals who had undergone allo-HCT. Study participants received a fecal suspension from an unrelated healthy donor via nasoduodenal infusion. Donor FMT was well tolerated, and infection-related adverse events did not seem to be related to the FMT procedure. In 10 of 15 study participants, a complete clinical response was observed within 1 month after FMT, without additional interventions to alleviate GvHD symptoms. This response was accompanied by an increase in gut microbial a-diversity, a partial engraft-ment of donor bacterial species, and increased abundance of butyrate-producing bacteria, including Clostridiales and Blautia species. In 6 of the 10 responding donor FMT recipients, immunosuppressant drug therapy was successfully tapered. Durable remission of steroid-refractory or steroid-dependent GvHD after donor FMT was associated with improved survival at 24 weeks after donor FMT. This study highlights the potential of donor FMT as a treatment for steroid-refractory or steroid-dependent GvHD, but larger clinical trials are needed to confirm the safety and efficacy of this procedure.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Davids, M. (author)
  • Haverkate, N. J. E. (author)
  • de Groot, P. F. (author)
  • Donker, M. L. (author)
  • Meijer, E. (author)
  • Heubel-Moenen, Fcji (author)
  • Nur, E. (author)
  • Zeerleder, S. S. (author)
  • Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xnieum (author)
  • Blom, B. (author)
  • Hazenberg, M. D. (author)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Related titles

  • In:Science Translational Medicine: American Association for the Advancement of Science (AAAS)12:5561946-62341946-6242

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