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Statin therapy is a...
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Vieira-Silva, S.Katholieke Universiteit Leuven,European Molecular Biology Laboratory
(author)
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-06
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/296905
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https://gup.ub.gu.se/publication/296905URI
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https://doi.org/10.1038/s41586-020-2269-xDOI
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https://research.chalmers.se/publication/517357URI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans1,2. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities1,2, and its prevalence varies from 13% in a general population cohort to as high as 78% in patients with inflammatory bowel disease2. Reported changes in stool consistency3 and inflammation status4 during the progression towards obesity and metabolic comorbidities led us to propose that these developments might similarly correlate with an increased prevalence of the potentially dysbiotic Bact2 enterotype. Here, by exploring obesity-associated microbiota alterations in the quantitative faecal metagenomes of the cross-sectional MetaCardis Body Mass Index Spectrum cohort (n=888), we identify statin therapy as a key covariate of microbiome diversification. By focusing on a subcohort of participants that are not medicated with statins, we find that the prevalence of Bact2 correlates with body mass index, increasing from 3.90% in lean or overweight participants to 17.73% in obese participants. Systemic inflammation levels in Bact2-enterotyped individuals are higher than predicted on the basis of their obesity status, indicative of Bact2 as a dysbiotic microbiome constellation. We also observe that obesity-associated microbiota dysbiosis is negatively associated with statin treatment, resulting in a lower Bact2 prevalence of 5.88% in statin-medicated obese participants. This finding is validated in both the accompanying MetaCardis cardiovascular disease dataset (n = 282) and the independent Flemish Gut Flora Project population cohort (n=2,345). The potential benefits of statins in this context will require further evaluation in a prospective clinical trial to ascertain whether the effect is reproducible in a randomized population and before considering their application as microbiota-modulating therapeutics. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Falony, G.Katholieke Universiteit Leuven
(author)
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Belda, E.
(author)
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Nielsen, T.Köpenhamns universitet,University of Copenhagen
(author)
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Aron-Wisnewsky, J.Köpenhamns universitet,University of Copenhagen
(author)
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Chakaroun, R.Universität Leipzig,Leipzig University
(author)
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Forslund, S. K.Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine
(author)
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Assmann, K.
(author)
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Valles-Colomer, M.Katholieke Universiteit Leuven,Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Nguyen, T. T. D.Katholieke Universiteit Leuven
(author)
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Proost, S.Katholieke Universiteit Leuven
(author)
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Prifti, E.
(author)
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Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtreva
(author)
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Pons, N.Université Paris-Saclay,University Paris-Saclay
(author)
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Le Chatelier, E.Université Paris-Saclay,University Paris-Saclay
(author)
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Andreelli, F.
(author)
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Bastard, J. P.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Coelho, L. P.European Molecular Biology Laboratory,Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Galleron, N.Université Paris-Saclay,University Paris-Saclay
(author)
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Hansen, T. H.Köpenhamns universitet,University of Copenhagen
(author)
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Hulot, J. S.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Lewinter, C.Köpenhamns universitet,University of Copenhagen
(author)
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Pedersen, H. K.Köpenhamns universitet,University of Copenhagen
(author)
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Quinquis, B.Université Paris-Saclay,University Paris-Saclay
(author)
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Rouault, C.
(author)
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Roume, H.Université Paris-Saclay,University Paris-Saclay
(author)
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Salem, J. E.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Søndertoft, N. B.Köpenhamns universitet,University of Copenhagen
(author)
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Touch, S.
(author)
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Alves, R.European Molecular Biology Laboratory
(author)
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Amouyal, C.
(author)
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Galijatovic, E. A. A.Köpenhamns universitet,University of Copenhagen
(author)
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Barthelemy, O.Assistance publique – Hôpitaux de Paris (AP-HP),Köpenhamns universitet,University of Copenhagen
(author)
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Batisse, J. P.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Berland, M.Université Paris-Saclay,University Paris-Saclay
(author)
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Bittar, R.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Blottière, H.Université Paris-Saclay,University Paris-Saclay
(author)
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Bosquet, F.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Boubrit, R.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Bourron, O.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Camus, M.Université Paris-Saclay,University Paris-Saclay
(author)
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Cassuto, D.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Ciangura, C.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Collet, J. P.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Dao, M. C.
(author)
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Debedat, J.
(author)
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Djebbar, M.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Doré, A.Université Paris-Saclay,University Paris-Saclay
(author)
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Engelbrechtsen, L.Köpenhamns universitet,University of Copenhagen
(author)
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Fellahi, S.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Fromentin, S.Université Paris-Saclay,University Paris-Saclay
(author)
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Giral, P.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Graine, M.
(author)
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Hartemann, A.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Hartmann, B.Köpenhamns universitet,University of Copenhagen
(author)
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Helft, G.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Hercberg, S.
(author)
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Hornbak, M.Köpenhamns universitet,University of Copenhagen
(author)
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Isnard, R.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Jaqueminet, S.
(author)
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Jørgensen, N. R.Köpenhamns universitet,University of Copenhagen
(author)
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Julienne, H.Université Paris-Saclay,University Paris-Saclay
(author)
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Justesen, J.
(author)
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Kammer, J.Universität Leipzig,Leipzig University
(author)
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Kerneis, M.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Khemis, J.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Krarup, N.Köpenhamns universitet,University of Copenhagen
(author)
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Kuhn, M.European Molecular Biology Laboratory
(author)
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Lampuré, A.
(author)
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Lejard, V.Université Paris-Saclay,University Paris-Saclay
(author)
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Levenez, F.Université Paris-Saclay,University Paris-Saclay
(author)
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Lucas-Martini, L.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Massey, R.Université Paris-Saclay,University Paris-Saclay
(author)
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Maziers, N.Université Paris-Saclay,University Paris-Saclay
(author)
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Medina-Stamminger, J.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Moitinho-Silva, L.European Molecular Biology Laboratory
(author)
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Montalescot, G.
(author)
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Moutel, S.Assistance publique – Hôpitaux de Paris (AP-HP),Universität Leipzig,Leipzig University
(author)
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Le Pavin, L. P.Université Paris-Saclay,University Paris-Saclay
(author)
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Poitou-Bernert, C.
(author)
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Pousset, F.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Pouzoulet, L.
(author)
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Schmidt, S.
(author)
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Silvain, J.
(author)
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Svendstrup, M.Köpenhamns universitet,University of Copenhagen
(author)
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Swartz, T.
(author)
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Vanduyvenboden, T.Université Paris-Saclay,University Paris-Saclay
(author)
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Vatier, C.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Verger, E.
(author)
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Walther, S.Universität Leipzig,Leipzig University
(author)
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Dumas, M. E.Imperial College of Science, Technology and Medicine
(author)
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Ehrlich, S. D.Université Paris-Saclay,University Paris-Saclay
(author)
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Galan, P.
(author)
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Gøtze, J. P.Köpenhamns universitet,University of Copenhagen
(author)
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Hansen, T.
(author)
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Holst, J. J.Köpenhamns universitet,University of Copenhagen
(author)
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Køber, L.Köpenhamns universitet,University of Copenhagen
(author)
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Letunic, I.Biobyte Solutions GmbH
(author)
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Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
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Oppert, J. M.Assistance publique – Hôpitaux de Paris (AP-HP)
(author)
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Stumvoll, M.
(author)
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Vestergaard, H.Köpenhamns universitet,University of Copenhagen
(author)
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Zucker, J. D.
(author)
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Bork, P.European Molecular Biology Laboratory
(author)
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Pedersen, O.
(author)
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Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Köpenhamns universitet,University of Copenhagen(Swepub:gu)xbafre
(author)
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Clément, K.
(author)
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Raes, J.Katholieke Universiteit Leuven
(author)
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Katholieke Universiteit LeuvenEuropean Molecular Biology Laboratory
(creator_code:org_t)
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In:Nature: Springer Science and Business Media LLC581:7808, s. 310-3150028-08361476-4687
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Vieira-Silva, S.
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Falony, G.
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Belda, E.
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Nielsen, T.
-
Aron-Wisnewsky, ...
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Chakaroun, R.
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show more...
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Forslund, S. K.
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Assmann, K.
-
Valles-Colomer, ...
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Nguyen, T. T. D.
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Proost, S.
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Prifti, E.
-
Tremaroli, Valen ...
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Pons, N.
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Le Chatelier, E.
-
Andreelli, F.
-
Bastard, J. P.
-
Coelho, L. P.
-
Galleron, N.
-
Hansen, T. H.
-
Hulot, J. S.
-
Lewinter, C.
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Pedersen, H. K.
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Quinquis, B.
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Rouault, C.
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Roume, H.
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Salem, J. E.
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Søndertoft, N. B ...
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Touch, S.
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Alves, R.
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Amouyal, C.
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Galijatovic, E. ...
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Barthelemy, O.
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Batisse, J. P.
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Berland, M.
-
Bittar, R.
-
Blottière, H.
-
Bosquet, F.
-
Boubrit, R.
-
Bourron, O.
-
Camus, M.
-
Cassuto, D.
-
Ciangura, C.
-
Collet, J. P.
-
Dao, M. C.
-
Debedat, J.
-
Djebbar, M.
-
Doré, A.
-
Engelbrechtsen, ...
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Fellahi, S.
-
Fromentin, S.
-
Giral, P.
-
Graine, M.
-
Hartemann, A.
-
Hartmann, B.
-
Helft, G.
-
Hercberg, S.
-
Hornbak, M.
-
Isnard, R.
-
Jaqueminet, S.
-
Jørgensen, N. R.
-
Julienne, H.
-
Justesen, J.
-
Kammer, J.
-
Kerneis, M.
-
Khemis, J.
-
Krarup, N.
-
Kuhn, M.
-
Lampuré, A.
-
Lejard, V.
-
Levenez, F.
-
Lucas-Martini, L ...
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Massey, R.
-
Maziers, N.
-
Medina-Stamminge ...
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Moitinho-Silva, ...
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Montalescot, G.
-
Moutel, S.
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Le Pavin, L. P.
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Poitou-Bernert, ...
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Pousset, F.
-
Pouzoulet, L.
-
Schmidt, S.
-
Silvain, J.
-
Svendstrup, M.
-
Swartz, T.
-
Vanduyvenboden, ...
-
Vatier, C.
-
Verger, E.
-
Walther, S.
-
Dumas, M. E.
-
Ehrlich, S. D.
-
Galan, P.
-
Gøtze, J. P.
-
Hansen, T.
-
Holst, J. J.
-
Køber, L.
-
Letunic, I.
-
Nielsen, Jens B, ...
-
Oppert, J. M.
-
Stumvoll, M.
-
Vestergaard, H.
-
Zucker, J. D.
-
Bork, P.
-
Pedersen, O.
-
Bäckhed, Fredrik ...
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Clément, K.
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Raes, J.
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