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Models of the blood...
Models of the blood-brain barrier using iPSC-derived cells
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- Delsing, Louise (author)
- Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Neurochem, Sahlgrenska Acad, Gothenburg, Sweden.;Univ Skövde, Syst Biol Res Ctr, Sch Biosci, Skövde, Sweden.;AstraZeneca, R&D, Discovery Sci, Discovery Biol, Mölndal, Sweden.,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Institute of Neuroscience and Physiology, Department of Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sweden / Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Mölndal, Sweden,Translationell bioinformatik, Translational Bioinformatics
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- Herland, Anna (author)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik,Karolinska Inst, Dept Neurosci, AIMES, Stockholm, Sweden.,Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden / AIMES, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
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- Falk, A. (author)
- Karolinska Institutet
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- Hicks, R. (author)
- AstraZeneca, R&D, Discovery Sci, Discovery Biol, Mölndal, Sweden.,Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Mölndal, Sweden
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- Synnergren, Jane (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translationell bioinformatik, Translational Bioinformatics
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Inst Neurosci & Physiol, Dept Neurochem, Sahlgrenska Acad, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;UCL Inst Neurol, Dept Neurodegenerat Dis, London, England.;UK Dementia Res Inst UCL, London, England.,Institute of Neuroscience and Physiology, Department of Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sweden / Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden / Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom / UK Dementia Research Institute at UCL, London, United Kingdom
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431 .- 1095-9327. ; 107
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Abstract
Subject headings
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- The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for studying the development and maintenance of the BBB as well as diseases affecting it. Furthermore, BBB models are important tools in drug development and support the evaluation of the brain-penetrating properties of novel drug molecules. Currently used in vitro models of the BBB include immortalized brain endothelial cell lines and primary brain endothelial cells of human and animal origin. Unfortunately, many cell lines and primary cells do not recreate physiological restriction of transport in vitro. Human-induced pluripotent stem cell (iPSC)-derived brain endothelial cells have proven a promising alternative source of brain endothelial-like cells that replicate tight cell layers with low paracellular permeability. Given the possibility to generate large amounts of human iPSC-derived brain endothelial cells they are a feasible alternative when modelling the BBB in vitro. iPSC-derived brain endothelial cells form tight cell layers in vitro and their barrier properties can be enhanced through co-culture with other cell types of the BBB. Currently, many different models of the BBB using iPSC-derived cells are under evaluation to study BBB formation, maintenance, disruption, drug transport and diseases affecting the BBB. This review summarizes important functions of the BBB and current efforts to create iPSC-derived BBB models in both static and dynamic conditions. In addition, it highlights key model requirements and remaining challenges for human iPSC-derived BBB models in vitro.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- iPSC
- Blood-brain barrier
- in vitro model
- Brain endothelial cells
- pluripotent stem-cells
- microvascular endothelial-cells
- in-vitro
- models
- glucose transporters
- electrical-resistance
- neurovascular unit
- tight junctions
- permeability
- pericytes
- differentiation
- Neurosciences & Neurology
- iPSC
- Bioinformatik
Publication and Content Type
- ref (subject category)
- art (subject category)
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