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Integration of mole...
Integration of molecular profiles in a longitudinal wellness profiling cohort.
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- Abdellah, Tebani (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Gummesson, Anders, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Zhong, Wen (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Koistinen, Ina Schuppe (author)
- Karolinska Institutet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Lakshmikanth, Tadepally (author)
- Karolinska Institutet
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- Olsson, Lisa M., 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Boulund, Fredrik, 1985 (author)
- Karolinska Institutet
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- Neiman, Maja, 1983- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Stenlund, Hans (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Hellström, Cecilia (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Karlsson, Max (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Arif, Muhammad (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Dodig-Crnkovic, Tea (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Mardinoglu, Adil (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England
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- Lee, Sunjae (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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Zhang, Cheng (author)
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- Chen, Yang (author)
- Karolinska Institutet
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Olin, Axel (author)
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- Mikes, Jaromir (author)
- Karolinska Institutet
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- Danielsson, Hanna (author)
- Karolinska Institutet
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- von Feilitzen, Kalle (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Jansson, Per-Anders, 1961 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Angerås, Oskar, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Huss, Mikael (author)
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- Kjellqvist, Sanela (author)
- Karolinska Institutet
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- Odeberg, Jacob, Professor, 1963- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Edfors, Fredrik (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Tremaroli, Valentina, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Forsström, Björn (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Moritz, Thomas (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Engstrand, Lars (author)
- Karolinska Institutet
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- Brodin, Petter (author)
- Karolinska Institutet
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Danish Tech Univ, Ctr Biosustainabil, Copenhagen, Denmark
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- Fagerberg, Linn (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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(creator_code:org_t)
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- 2020-09-08
- 2020
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
- Related links:
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https://www.nature.c...
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https://pub.epsilon.... (primary) (Raw object) (free)
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Aged
- Cohort Studies
- Female
- Healthy Aging
- genetics
- metabolism
- Healthy Volunteers
- Humans
- Lipidomics
- Longitudinal Studies
- Male
- Metabolome
- Metabolomics
- Middle Aged
- Precision Medicine
- Prospective Studies
- Proteome
- metabolism
- Proteomics
- Sweden
- Transcriptome
- General Physics and Astronomy
- Bioteknologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abdellah, Tebani
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Gummesson, Ander ...
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Zhong, Wen
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Koistinen, Ina S ...
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Lakshmikanth, Ta ...
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Olsson, Lisa M., ...
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show more...
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Boulund, Fredrik ...
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Neiman, Maja, 19 ...
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Stenlund, Hans
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Hellström, Cecil ...
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Karlsson, Max
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Arif, Muhammad
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Dodig-Crnkovic, ...
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Mardinoglu, Adil
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Lee, Sunjae
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Zhang, Cheng
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Chen, Yang
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Olin, Axel
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Mikes, Jaromir
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Danielsson, Hann ...
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von Feilitzen, K ...
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Jansson, Per-And ...
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Angerås, Oskar, ...
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Huss, Mikael
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Kjellqvist, Sane ...
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Odeberg, Jacob, ...
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Edfors, Fredrik
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Tremaroli, Valen ...
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Forsström, Björn
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Schwenk, Jochen ...
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Nilsson, Peter
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Moritz, Thomas
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Bäckhed, Fredrik ...
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Engstrand, Lars
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Brodin, Petter
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Bergström, Göran ...
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Uhlén, Mathias
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Fagerberg, Linn
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Nature communica ...
- By the university
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University of Gothenburg
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Swedish University of Agricultural Sciences
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Umeå University
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Royal Institute of Technology
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Karolinska Institutet