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Randomised comparis...
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Kumsars, IndulisDepartment of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
(author)
Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch : the Nordic-Baltic Bifurcation Study IV
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-19
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BMJ Publishing Group Ltd,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-81576
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81576URI
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https://doi.org/10.1136/openhrt-2018-000947DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agency:Cordis Corp
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Background: It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.Methods: The study was a randomised, superiority trial. Enrolment required a SB >= 2.75 mm, >= 50% diameter stenosis in both vessels, and allowed SB lesion length up to 15 mm. The primary endpoint was a composite of cardiac death, non-procedural myocardial infarction and target lesion revascularisation at 6 months. Two-year clinical follow-up was included in this primary reporting due to lower than expected event rates.Results: A total of 450 patients were assigned to simple stenting (n = 221) or complex stenting (n=229) in 14 Nordic and Baltic centres. Two-year follow-up was available in 218 (98.6%) and 228 (99.5%) patients, respectively. The primary endpoint of major adverse cardiac events (MACE) at 6 months was 5.5% vs 2.2% (risk differences 3.2%, 95% CI -0.2 to 6.8, p=0.07) and at 2 years 12.9% vs 8.4% (HR 0.63, 95% CI 0.35 to 1.13, p = 0.12) after simple versus complex treatment. In the subgroup treated by newer generation drug-eluting stents, MACE was 12.0% vs 5.6% (HR 0.45, 95% CI 0.17 to 1.17, p = 0.10) after simple versus complex treatment.Conclusion: In the treatment of bifurcation lesions involving a large SB with ostial stenosis, routine two-stent techniques did not improve outcome significantly compared with treatment by the simpler main vessel stenting technique after 2 years.
Subject headings and genre
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Holm, Niels RamsingDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Niemelä, MattiDepartment of Cardiology, Oulu University Hospital, Oulu, Finland
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Erglis, AndrejsResearch Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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Kervinen, KariDepartment of Cardiology, Oulu University Hospital, Oulu, Finland
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Christiansen, Evald HojDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Maeng, MichaelDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Dombrovskis, AndisDepartment of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
(author)
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Abraitis, VytautasDepartment of Cardiology, Vilnius University Hospital, Vilnius, Lithuania
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Kibarskis, AleksandrasDepartment of Cardiology, Vilnius University Hospital, Vilnius, Lithuania
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Trovik, ThorDepartment of Cardiology, University of North Norway, Tromsoe, Norway
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Latkovskis, GustavsResearch Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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Sondore, DaceDepartment of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
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Narbute, IngaResearch Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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Terkelsen, Christian JuhlDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Eskola, MarkkuDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
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Romppanen, HannuDepartment of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland
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Laine, MikaDepartment of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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Jensen, Lisette OkkelsDepartment of Cardiology, Odense University Hospital, Odense, Denmark
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Pietila, MikkoDepartment of Cardiology, Turku University Hospital, Turku, Finland
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Gunnes, PalHeart Center, Sørlandet Hospital, Arendal, Norway
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Hebsgaard, LasseDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology(Swepub:oru)oft
(author)
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Calais, Fredrik,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology(Swepub:oru)fcs
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Hartikainen, JuhaDepartment of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland
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Aarøe, JensDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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Ravkilde, JanDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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Engstrøm, ThomasDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark
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Steigen, Terje K.Department of Cardiology, University Hospital of North Norway, Tromsoe and Cardiovascular Diseases Research Group, UiT The Arctic University of Norway, Tromsø, Norway
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Thuesen, LeifDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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Lassen, Jens F.Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, LatviaDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark
(creator_code:org_t)
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Kumsars, Indulis
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Holm, Niels Rams ...
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Niemelä, Matti
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Erglis, Andrejs
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Kervinen, Kari
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Christiansen, Ev ...
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Maeng, Michael
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Dombrovskis, And ...
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Trovik, Thor
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Latkovskis, Gust ...
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Sondore, Dace
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Narbute, Inga
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Terkelsen, Chris ...
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Eskola, Markku
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Romppanen, Hannu
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Laine, Mika
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Jensen, Lisette ...
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Pietila, Mikko
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Gunnes, Pal
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Hebsgaard, Lasse
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Fröbert, Ole, 19 ...
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Calais, Fredrik, ...
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Hartikainen, Juh ...
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Aarøe, Jens
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Ravkilde, Jan
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Engstrøm, Thomas
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Thuesen, Leif
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