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Pediatric brain tum...
Pediatric brain tumor care in a Sub-Saharan setting: current poise of a precariously loaded dice
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- Uche, E. O. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Eke, C. B. (författare)
- Univ Nigeria, Dept Pediat, Ituku Ozalla Campus, Enugu, Nigeria.
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- Okafor, O. C. (författare)
- Univ Nigeria, Dept Morbid & Anat Pathol, Ituku Ozalla Campus, Enugu, Nigeria.
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- Uche, N. J. (författare)
- Univ Nigeria, Dept Ophthalmol, Ituku Ozalla Campus, Enugu, Nigeria.
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- Ajuzieogu, O. V. (författare)
- Univ Nigeria, Dept Anaesthesia, Ituku Ozalla Campus, Enugu, Nigeria.
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- Amuta, D. S. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Onyia, E. E. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Guga, D. A. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Okpara, S. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Mezue, W. C. (författare)
- Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria.
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- Tisell, Magnus, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Univ Gothenburg, Inst Neurosci & Physiol, Dept Clin Neurosci & Rehabil, Gothenburg, Sweden.
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- Ryttlefors, Mats (författare)
- Uppsala universitet,Enblad: Neurokirurgi
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Univ Nigeria, Div Neurosurg, Ituku Ozalla Campus, Enugu, Nigeria Univ Nigeria, Dept Pediat, Ituku Ozalla Campus, Enugu, Nigeria. (creator_code:org_t)
- 2020-07-13
- 2021
- Engelska.
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Ingår i: British Journal of Neurosurgery. - : Informa UK Limited. - 0268-8697 .- 1360-046X. ; 35:2, s. 174-180
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To evaluate the current status of pediatric brain tumor (PBT) care and identify determinants and profiles of survival and school attendance Methods: An 8-year institution-based prospective longitudinal study. All cases investigated with neuroimaging and treated were enrolled. Data was analyzed with SPSS (Inc) Chicago IL, USA version 23. Chi Square test, One-way ANOVA and confidence limits were used to evaluate associations at the 95% level of significance. Ethical approval for our study was obtained Health Research Ethics Committee of our hospital. Results: Among 103 patients enrolled, 92 satisfied our study criteria. There were 45 males and 39 females, M: F = 0.8. The mean age was 9.5 ± 2.1 years 95%CI with a range of 7 months to 16 years. The most common symptom was headache for supratentorial lesions (73%) and gait disturbance (80.2%) for infratentorial lesions. More tumors were supratentorial in location 51 (55.4%), 35 (38.1%) were infratentorial and 6 (6.5%) were transtentorial. Craniopharyngiomas (n = 23), medulloblastomas (n = 22) and astrocytomas (n = 15) were the most common tumors. Hemoglobin genotype (AA and AS) had some influence on tumor phenotype FT, P = 0.033. 76 cases were microsurgically resected while 16 patients were treated with radiotherapy alone. The 30-day mortality for operated cases is 7.2 ± 0.7%. Overall 1-year and 5-year survival was 66.7 and 52.3%, respectively. School attendance, performance and outcome varied among treatment subgroups. Conclusion: Survival profile in this series suggests some improvement in comparison to previous studies from our region, Hemoglobin genotype profiles may signature paediatric brain tumor phenotypes in our setting. © 2020, © 2020 The Neurosurgical Foundation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- micro neurosurgery
- Pediatric brain tumors
- radiotherapy
- school performance
- survival
- hemoglobin A
- academic achievement
- adolescent
- Africa south of the Sahara
- Article
- astrocytoma
- brain tumor
- cancer mortality
- child
- childhood cancer
- craniopharyngioma
- ependymoma
- female
- genotype phenotype correlation
- glioma
- headache
- human
- infant
- longitudinal study
- major clinical study
- male
- medulloblastoma
- microsurgery
- neuroectoderm tumor
- neuroimaging
- neurologic gait disorder
- oligodendroglioma
- overall survival
- patient care
- priority journal
- prospective study
- school attendance
- survival rate
- survival time
- treatment outcome
- tumor localization
- Pediatric brain tumors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Uche, E. O.
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Eke, C. B.
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Okafor, O. C.
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Uche, N. J.
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Ajuzieogu, O. V.
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Amuta, D. S.
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visa fler...
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Onyia, E. E.
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Guga, D. A.
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Okpara, S.
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Mezue, W. C.
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Tisell, Magnus, ...
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Ryttlefors, Mats
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Göteborgs universitet
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