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Genomic and drug ta...
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
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- Folkersen, Lasse (author)
- Danish National Genome Center
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- Gustafsson, Stefan (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Wang, Qin (author)
- University of Oulu
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show more...
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- Hansen, Daniel Hvidberg (author)
- Intomics A/S
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- Hedman, Åsa K (author)
- Karolinska Institutet,Karolinska Institute,Pfizer Limited, UK
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- Schork, Andrew (author)
- Translational Genomics Research Institute (TGen)
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- Page, Karen (author)
- Pfizer Inc. US
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- Zhernakova, Daria V (author)
- University of Groningen
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- Wu, Yang (author)
- University of Queensland
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- Peters, James (author)
- Imperial College London,University of Cambridge
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- Eriksson, Niclas, 1978- (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Bergen, Sarah E (author)
- Karolinska Institutet,Karolinska Institute
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- Boutin, Thibaud S (author)
- University of Edinburgh
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- Bretherick, Andrew D (author)
- SCALLOP consortium
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- Enroth, Stefan, 1976- (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten
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- Kalnapenkis, Anette (author)
- SCALLOP consortium
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- Gådin, Jesper R (author)
- Karolinska Institutet
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- Suur, Bianca E (author)
- Karolinska Institutet
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- Chen, Yan (author)
- Karolinska Institutet,Karolinska Institute
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- Matic, Ljubica (author)
- Karolinska Institutet
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- Gale, Jeremy D (author)
- SCALLOP consortium
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- Lee, Julie (author)
- SCALLOP consortium
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- Zhang, Weidong (author)
- SCALLOP consortium
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- Quazi, Amira (author)
- SCALLOP consortium
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- Ala-Korpela, Mika (author)
- SCALLOP consortium
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- Choi, Seung Hoan (author)
- SCALLOP consortium
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- Claringbould, Annique (author)
- SCALLOP consortium
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- Danesh, John (author)
- SCALLOP consortium
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- Davey Smith, George (author)
- SCALLOP consortium
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- de Masi, Federico (author)
- SCALLOP consortium
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- Elmståhl, Sölve (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
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Fauman, Eric (author)
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- Fernandez, Celine (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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Franke, Lude (author)
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- Franks, Paul W (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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Haley, Chris (author)
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- Hamsten, Anders (author)
- Karolinska Institutet
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Ingason, Andres (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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Joshi, Peter K (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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- Lindgren, Cecilia M (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital
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Lubitz, Steven (author)
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Palmer, Tom (author)
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Macdonald-Dunlop, Erin (author)
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- Nilsson, Peter M (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Michaëlsson, Karl, 1959- (author)
- Uppsala universitet,Ortopedi
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Morris, Andrew P (author)
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Mägi, Reedik (author)
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Nagle, Michael W (author)
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Nilsson, Peter M (author)
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Polasek, Ozren (author)
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Prins, Bram (author)
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Pålsson, Erik (author)
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Qi, Ting (author)
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- Sjögren, Marketa (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genetic and Molecular Epidemiology,Lund University Research Groups,Cardiovascular Research - Hypertension,Skåne University Hospital
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
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Surendran, Praveen (author)
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Võsa, Urmo (author)
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Werge, Thomas (author)
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Wernersson, Rasmus (author)
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Westra, Harm-Jan (author)
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Yang, Jian (author)
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Zhernakova, Alexandra (author)
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- Ärnlöv, Johan (author)
- Karolinska Institutet
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Fu, Jingyuan (author)
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- Smith, Gustav (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine
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Esko, Tõnu (author)
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Hayward, Caroline (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Klinisk kemi
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Wilson, James F (author)
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- Wallentin, Lars, 1943- (author)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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Butterworth, Adam S (author)
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Holmes, Michael V (author)
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Ingelsson, Erik (author)
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- Mälarstig, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-16
- 2020
- English.
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In: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
- Related links:
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https://pure.rug.nl/...
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Folkersen, Lasse
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Gustafsson, Stef ...
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Wang, Qin
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Hansen, Daniel H ...
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Hedman, Åsa K
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Schork, Andrew
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Page, Karen
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Zhernakova, Dari ...
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Wu, Yang
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Peters, James
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Eriksson, Niclas ...
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Bergen, Sarah E
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Boutin, Thibaud ...
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Bretherick, Andr ...
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Enroth, Stefan, ...
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Kalnapenkis, Ane ...
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Gådin, Jesper R
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Suur, Bianca E
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Chen, Yan
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Matic, Ljubica
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Gale, Jeremy D
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Lee, Julie
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Zhang, Weidong
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Quazi, Amira
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Ala-Korpela, Mik ...
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Choi, Seung Hoan
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Claringbould, An ...
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Danesh, John
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Davey Smith, Geo ...
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de Masi, Federic ...
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Elmståhl, Sölve
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Engström, Gunnar
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Fauman, Eric
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Fernandez, Celin ...
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Franke, Lude
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Franks, Paul W
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Giedraitis, Vilm ...
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Haley, Chris
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Hamsten, Anders
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Ingason, Andres
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Johansson, Åsa
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Joshi, Peter K
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Lind, Lars
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Lindgren, Cecili ...
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Lubitz, Steven
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Palmer, Tom
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Macdonald-Dunlop ...
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Nilsson, Peter M
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Melander, Olle
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Michaëlsson, Kar ...
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Morris, Andrew P
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Mägi, Reedik
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Nagle, Michael W
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Nilsson, Jan
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Orho-Melander, M ...
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Polasek, Ozren
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Prins, Bram
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Pålsson, Erik
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Qi, Ting
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Sjögren, Marketa
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Sundström, Johan ...
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Surendran, Prave ...
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Võsa, Urmo
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Werge, Thomas
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Wernersson, Rasm ...
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Westra, Harm-Jan
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Yang, Jian
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Zhernakova, Alex ...
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Ärnlöv, Johan
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Fu, Jingyuan
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Smith, Gustav
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Esko, Tõnu
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Hayward, Carolin ...
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Gyllensten, Ulf
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Landén, Mikael, ...
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Siegbahn, Agneta ...
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Wilson, James F
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Wallentin, Lars, ...
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Butterworth, Ada ...
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Holmes, Michael ...
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Ingelsson, Erik
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Mälarstig, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature metabolis ...
- By the university
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University of Gothenburg
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Uppsala University
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Lund University
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Karolinska Institutet