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Amyloid-PET and 18-...
Amyloid-PET and 18-F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
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- Chetelat, G. (author)
- University of Caen Normandy
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- Arbizu, J. (author)
- University of Navarra,University Clinic of Navarra
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- Barthel, H. (author)
- University Hospital Leipzig
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- Garibotto, V. (author)
- University of Geneva,Geneva University Hospital
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- Law, I. (author)
- Copenhagen University Hospital
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- Morbelli, S. (author)
- Ospedale Policlinico San Martino,University of California, Berkeley
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- van de Giessen, E. (author)
- University of Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Agosta, F. (author)
- Vita-Salute San Raffaele University,San Raffaele Scientific Institute
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- Barkhof, F. (author)
- University College London,Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam,Geneva University Hospital,University of Geneva
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- Brooks, D. J. (author)
- University of Newcastle upon Tyne,Aarhus University Hospital
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- Carrillo, M. C. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
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- Dubois, B. (author)
- Paris-Sorbonne University,Pitié-Salpêtrière University Hospital
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- Fjell, A. M. (author)
- Oslo university hospital,University of Oslo
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Frisoni, G. B. (author)
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Herholz, K. (author)
- University of Manchester
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- Hutton, B. F. (author)
- University College London
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- Jack, C. R. (author)
- Mayo Clinic Minnesota
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- Lammertsma, A. A. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Landau, S. M. (author)
- University of Utah
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Minoshima, S. (author)
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- Nobili, F. (author)
- University of Genoa,Ospedale Policlinico San Martino
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- Nordberg, A. (author)
- Karolinska Institutet,Karolinska Institute
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Oyen, W. J. G. (author)
- Rijnstate Hospital,Radboud University Medical Center,Humanitas University,Humanitas Research Hospital
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- Perani, D. (author)
- San Raffaele Hospital,Vita-Salute San Raffaele University
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- Rabinovici, G. D. (author)
- University of California, San Francisco
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- Scheltens, P. (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Villemagne, V. L. (author)
- University of Melbourne,Edith Cowan University,Austin Health
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- Zetterberg, Henrik, 1973 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,University College London
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- Drzezga, A. (author)
- University of Cologne,German Center for Neurodegenerative Diseases (DZNE), Bonn,Jülich Research Centre
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Lancet Neurology. - 1474-4422 .- 1474-4465. ; 19:11, s. 951-962
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and F-18-fluorodeoxyglucose (F-18-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an order in which these PET biomarkers should be used in diagnostic evaluations because conclusive evidence is missing. Following an expert panel discussion, we reached an agreement on the specific use of the individual biomarkers, based on available evidence and clinical expertise. We propose a diagnostic algorithm with optimal timepoints for these PET biomarkers, also taking into account evidence from other biomarkers, for early and differential diagnosis of neurodegenerative diseases that can lead to dementia. We propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and F-18-FDG-PET are placed at different positions in the order of diagnostic evaluations, depending on clinical presentation. We hope that this algorithm can support diagnostic decision making in specialist clinical settings with access to these biomarkers and might stimulate further research towards optimal diagnostic strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- mild cognitive impairment
- progressive supranuclear palsy
- cerebrospinal-fluid biomarkers
- positron-emission-tomography
- differential-diagnosis
- clinical-diagnosis
- national institute
- csf
- biomarkers
- fdg-pet
- a-beta
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- for (subject category)
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To the university's database
- By the author/editor
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Chetelat, G.
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Arbizu, J.
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Barthel, H.
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Garibotto, V.
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Law, I.
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Morbelli, S.
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show more...
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van de Giessen, ...
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Agosta, F.
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Barkhof, F.
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Brooks, D. J.
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Carrillo, M. C.
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Dubois, B.
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Fjell, A. M.
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Frisoni, G. B.
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Hansson, Oskar
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Herholz, K.
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Hutton, B. F.
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Jack, C. R.
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Lammertsma, A. A ...
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Landau, S. M.
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Minoshima, S.
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Nobili, F.
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Nordberg, A.
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Ossenkoppele, Ri ...
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Oyen, W. J. G.
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Perani, D.
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Rabinovici, G. D ...
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Scheltens, P.
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Villemagne, V. L ...
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Zetterberg, Henr ...
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Drzezga, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Lancet Neurology
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet