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- Dionigi, CarlottaGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology (author)
Cellular expression of DNA damage/repair and reactive oxygen/nitrogen species in human periodontitis and peri-implantitis lesions
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-11-09
- Wiley,2020
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/298309
- https://gup.ub.gu.se/publication/298309URI
- https://doi.org/10.1111/jcpe.13370DOI
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- Language:English
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- SwePubSwePub
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Notes
- Aim of the study To evaluate differences in the cellular expression of DNA damage/repair and reactive oxygen/nitrogen species between human periodontitis and peri-implantitis lesions. Material and methods 40 patients presenting with generalized severe periodontitis and 40 patients with severe peri-implantitis were included. Soft tissue biopsies were collected from diseased sites in conjunction with surgical therapy and prepared for histological analysis. Four regions of interest were identified: the pocket epithelium (PE), the infiltrated connective tissue (ICT), which was divided into one inner area facing the PE (ICT-1) and one outer area (ICT-2). A non-infiltrated connective tissue area (NCT) lateral of the ICT was also selected. Results It was demonstrated that the ICT of peri-implantitis specimens was considerably larger and contained significantly larger area proportions and densities of CD68-, MPO- and iNOS-positive cells than that of periodontitis samples. Cellular densities were overall higher in the inner ICT zone lateral of the PE (ICT-1) than in the outer ICT compartment (ICT-2). While the NCT area lateral of the ICT comprised significantly larger proportions and densities of y-H2AX-, iNOS-, NOX2-, MPO- and PAD4/MPO-positive cells in peri-implantitis than in periodontitis sites, a reverse difference was noted for the area proportion and density of 8-OHdG-positive cells in the PE. Conclusions It is suggested that peri-implantitis lesions are associated with an enhanced and upregulated host response and contain larger numbers of neutrophils, macrophages and iNOS-positive cells than periodontitis lesions.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
- biopsy
- cell density
- histology
- immunohistochemistry
- inflammation
- peri‐
- implant disease
- periodontal disease
- 2017 world workshop
- immunohistochemical characteristics
- consensus
- report
- classification
- diseases
- tissues
- pattern
- Dentistry
- Oral Surgery & Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Larsson, Lena,1969Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xlleni (author)
- Carcuac, Olivier,1974Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xcarol (author)
- Berglundh, Tord,1954Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology(Swepub:gu)xbetor (author)
- Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)
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- In:Journal of Clinical Periodontology: Wiley47:12, s. 1466-14750303-69791600-051X
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