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Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry.
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-08-25
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Oxford University Press (OUP),2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/298561
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https://gup.ub.gu.se/publication/298561URI
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https://doi.org/10.1093/eurheartj/ehaa455DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We sought to describe the clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy (PPCM) globally.In 2011, >100 national and affiliated member cardiac societies of the European Society of Cardiology (ESC) were contacted to contribute to a global registry on PPCM, under the auspices of the ESC EURObservational Research Programme. These societies were tasked with identifying centres who could participate in this registry. In low-income countries, e.g. Mozambique or Burkina Faso, where there are no national societies due to a shortage of cardiologists, we identified potential participants through abstracts and publications and encouraged participation into the study. Seven hundred and thirty-nine women were enrolled in 49 countries in Europe (33%), Africa (29%), Asia-Pacific (15%), and the Middle East (22%). Mean age was 31±6years, mean left ventricular ejection fraction (LVEF) was 31±10%, and 10% had a previous pregnancy complicated by PPCM. Symptom-onset occurred most often within 1month of delivery (44%). At diagnosis, 67% of patients had severe (NYHA III/IV) symptoms and 67% had a LVEF ≤35%. Fifteen percent received bromocriptine with significant regional variation (Europe 15%, Africa 26%, Asia-Pacific 8%, the Middle East 4%, P<0.001). Follow-up was available for 598 (81%) women. Six-month mortality was 6% overall, lowest in Europe (4%), and highest in the Middle East (10%). Most deaths were due to heart failure (42%) or sudden (30%). Re-admission for any reason occurred in 10% (with just over half of these for heart failure) and thromboembolic events in 7%. Myocardial recovery (LVEF > 50%) occurred only in 46%, most commonly in Asia-Pacific (62%), and least commonly in the Middle East (25%). Neonatal death occurred in 5% with marked regional variation (Europe 2%, the Middle East 9%).Peripartum cardiomyopathy is a global disease, but clinical presentation and outcomes vary by region. Just under half of women experience myocardial recovery. Peripartum cardiomyopathy is a disease with substantial maternal and neonatal morbidity and mortality.
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Petrie, Mark C
(author)
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van der Meer, Peter
(author)
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Mebazaa, Alexandre
(author)
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Hilfiker-Kleiner, Denise
(author)
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Jackson, Alice M
(author)
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Maggioni, Aldo P
(author)
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Laroche, Cecile
(author)
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Regitz-Zagrosek, Vera
(author)
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Schaufelberger, Maria,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xscmar
(author)
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Tavazzi, Luigi
(author)
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Roos-Hesselink, Jolien W
(author)
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Seferovic, Petar
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van Spaendonck-Zwarts, Karin
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Mbakwem, Amam
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Böhm, Michael
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Mouquet, Frederic
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Pieske, Burkert
(author)
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Johnson, Mark R
(author)
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Hamdan, Righab
(author)
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Ponikowski, Piotr
(author)
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Van Veldhuisen, Dirk J
(author)
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McMurray, John J V
(author)
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Bauersachs, Johann
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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In:European heart journal: Oxford University Press (OUP)41:39, s. 3787-37971522-96450195-668X
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Sliwa, Karen
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Petrie, Mark C
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van der Meer, Pe ...
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Jackson, Alice M
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Maggioni, Aldo P
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Laroche, Cecile
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Regitz-Zagrosek, ...
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Tavazzi, Luigi
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Roos-Hesselink, ...
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Seferovic, Petar
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van Spaendonck-Z ...
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Mbakwem, Amam
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Böhm, Michael
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Mouquet, Frederi ...
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Pieske, Burkert
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Johnson, Mark R
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Hamdan, Righab
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Ponikowski, Piot ...
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University of Gothenburg