Search: WFRF:(Gisladottir Rosa S.) >
Sequence Variants i...
Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming.
-
Gisladottir, Rosa S (author)
-
Ivarsdottir, Erna V (author)
-
Helgason, Agnar (author)
-
show more...
-
- Jonsson, Lina, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Pharmacology,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Hannesdottir, Nanna K (author)
-
Rutsdottir, Gudrun (author)
-
Arnadottir, Gudny A (author)
-
Skuladottir, Astros (author)
-
Jonsson, Benedikt A (author)
-
Norddahl, Gudmundur L (author)
-
Ulfarsson, Magnus O (author)
-
Helgason, Hannes (author)
-
Halldorsson, Bjarni V (author)
-
Nawaz, Muhammad S (author)
-
Tragante, Vinicius (author)
-
Sveinbjornsson, Gardar (author)
-
Thorgeirsson, Thorgeir (author)
-
Oddsson, Asmundur (author)
-
Kristjansson, Ragnar P (author)
-
Bjornsdottir, Gyda (author)
-
Thorgeirsson, Gudmundur (author)
-
Jonsdottir, Ingileif (author)
-
Holm, Hilma (author)
-
Gudbjartsson, Daniel F (author)
-
Thorsteinsdottir, Unnur (author)
-
Stefansson, Hreinn (author)
-
Sulem, Patrick (author)
-
Stefansson, Kari (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
-
In: Current biology : CB. - : Elsevier BV. - 1879-0445 .- 0960-9822. ; 30:23
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Olfactory receptor (OR) genes in humans form a special class characterized by unusually high DNA sequence diversity, which should give rise to differences in perception and behavior. In the largest genome-wide association study to date based on olfactory testing, we investigated odor perception and naming with smell tasks performed by 9,122 Icelanders, with replication in a separate sample of 2,204 individuals. We discovered an association between a low-frequency missense variant in TAAR5 and reduced intensity rating of fish odor containing trimethylamine (p.Ser95Pro, pcombined= 5.6× 10-15). We demonstrate that TAAR5 genotype affects aversion to fish odor, reflected by linguistic descriptions of the odor and pleasantness ratings. We also discovered common sequence variants in two canonical olfactory receptor loci that associate with increased intensity and naming of licorice odor (trans-anethole: lead variant p.Lys233Asn in OR6C70, pcombined= 8.8× 10-16 and pcombined= 1.4× 10-9) and enhanced naming of cinnamon (trans-cinnamaldehyde; intergenic variant rs317787-T, pcombined= 5.0× 10-17). Together, our results show that TAAR5 genotype variation influences human odor responses and highlight that sequence diversity in canonical OR genes can lead to enhanced olfactory ability, in contrast to the view that greater tolerance for mutations in the human OR repertoire leads to diminished function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Olfaction
- TAAR5
- genome-wide association study
- odor naming; odor perception
- olfactory language
- trans-anethole
- trans-cinnamaldehyde; trimethylamine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gisladottir, Ros ...
-
Ivarsdottir, Ern ...
-
Helgason, Agnar
-
Jonsson, Lina, 1 ...
-
Hannesdottir, Na ...
-
Rutsdottir, Gudr ...
-
show more...
-
Arnadottir, Gudn ...
-
Skuladottir, Ast ...
-
Jonsson, Benedik ...
-
Norddahl, Gudmun ...
-
Ulfarsson, Magnu ...
-
Helgason, Hannes
-
Halldorsson, Bja ...
-
Nawaz, Muhammad ...
-
Tragante, Vinici ...
-
Sveinbjornsson, ...
-
Thorgeirsson, Th ...
-
Oddsson, Asmundu ...
-
Kristjansson, Ra ...
-
Bjornsdottir, Gy ...
-
Thorgeirsson, Gu ...
-
Jonsdottir, Ingi ...
-
Holm, Hilma
-
Gudbjartsson, Da ...
-
Thorsteinsdottir ...
-
Stefansson, Hrei ...
-
Sulem, Patrick
-
Stefansson, Kari
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Current biology ...
- By the university
-
University of Gothenburg