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Five-Year Outcomes ...
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Robert, Caroline
(författare)
Five-Year Outcomes With Nivolumab in Patients With Wild-Type BRAF Advanced Melanoma.
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/299036
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https://gup.ub.gu.se/publication/299036URI
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https://doi.org/10.1200/JCO.20.00995DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The CheckMate 066 trial investigated nivolumab monotherapy as first-line treatment for patients with previously untreated BRAF wild-type advanced melanoma. Five-year results are presented herein.In this multicenter, double-blind, phase III study, 418 patients with previously untreated, unresectable, stage III/IV, wild-type BRAF melanoma were randomly assigned 1:1 to receive nivolumab 3 mg/kg every 2 weeks or dacarbazine 1,000 mg/m2 every 3 weeks. The primary end point was overall survival (OS), and secondary end points included progression-free survival (PFS), objective response rate (ORR), and safety.Patients were followed for a minimum of 60 months from the last patient randomly assigned (median follow-up, 32.0 months for nivolumab and 10.9 months for dacarbazine). Five-year OS rates were 39% with nivolumab and 17% with dacarbazine; PFS rates were 28% and 3%, respectively. Five-year OS was 38% in patients randomly assigned to dacarbazine who had subsequent therapy, including nivolumab (n = 37). ORR was 42% with nivolumab and 14% with dacarbazine; among patients alive at 5 years, ORR was 81% and 39%, respectively. Of 42 patients treated with nivolumab who had a complete response (20%), 88% (37 of 42) were alive as of the 5-year analysis. Among 75 nivolumab-treated patients alive and evaluable at the 5-year analysis, 83% had not received subsequent therapy; 23% were still on study treatment, and 60% were treatment free. Safety analyses were similar to the 3-year report.Results from this 5-year analysis confirm the significant benefit of nivolumab over dacarbazine for all end points and add to the growing body of evidence supporting long-term survival with nivolumab mono-therapy. Survival is strongly associated with achieving a durable response, which can be maintained after treatment discontinuation, even without subsequent systemic therapies.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Long, Georgina V
(författare)
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Brady, Benjamin
(författare)
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Dutriaux, Caroline
(författare)
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Di Giacomo, Anna Maria
(författare)
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Mortier, Laurent
(författare)
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Rutkowski, Piotr
(författare)
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Hassel, Jessica C
(författare)
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McNeil, Catriona M
(författare)
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Kalinka, Ewa Anna
(författare)
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Lebbé, Céleste
(författare)
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Charles, Julie
(författare)
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Hernberg, Micaela M
(författare)
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Savage, Kerry J
(författare)
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Chiarion-Sileni, Vanna
(författare)
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Mihalcioiu, Catalin
(författare)
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Mauch, Cornelia
(författare)
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Arance, Ana
(författare)
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Cognetti, Francesco
(författare)
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Ny, Lars,1967Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xnylai
(författare)
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Schmidt, Henrik
(författare)
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Schadendorf, Dirk
(författare)
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Gogas, Helen
(författare)
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Zoco, Jesús
(författare)
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Re, Sandra
(författare)
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Ascierto, Paolo A
(författare)
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Atkinson, Victoria
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology38:33, s. 3937-39461527-7755
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Till lärosätets databas
- Av författaren/redakt...
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Robert, Caroline
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Long, Georgina V
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Brady, Benjamin
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Dutriaux, Caroli ...
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Di Giacomo, Anna ...
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Mortier, Laurent
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visa fler...
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Rutkowski, Piotr
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Hassel, Jessica ...
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McNeil, Catriona ...
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Kalinka, Ewa Ann ...
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Lebbé, Céleste
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Charles, Julie
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Hernberg, Micael ...
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Savage, Kerry J
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Chiarion-Sileni, ...
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Mihalcioiu, Cata ...
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Mauch, Cornelia
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Arance, Ana
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Cognetti, France ...
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Ny, Lars, 1967
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Schmidt, Henrik
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Schadendorf, Dir ...
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Gogas, Helen
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Zoco, Jesús
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Re, Sandra
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Ascierto, Paolo ...
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Atkinson, Victor ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Journal of clini ...
- Av lärosätet
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Göteborgs universitet