Sökning: WFRF:(Mihalcioiu Catalin) >
Five-Year Outcomes ...
Five-Year Outcomes With Nivolumab in Patients With Wild-Type BRAF Advanced Melanoma.
-
Robert, Caroline (författare)
-
Long, Georgina V (författare)
-
Brady, Benjamin (författare)
-
visa fler...
-
Dutriaux, Caroline (författare)
-
Di Giacomo, Anna Maria (författare)
-
Mortier, Laurent (författare)
-
Rutkowski, Piotr (författare)
-
Hassel, Jessica C (författare)
-
McNeil, Catriona M (författare)
-
Kalinka, Ewa Anna (författare)
-
Lebbé, Céleste (författare)
-
Charles, Julie (författare)
-
Hernberg, Micaela M (författare)
-
Savage, Kerry J (författare)
-
Chiarion-Sileni, Vanna (författare)
-
Mihalcioiu, Catalin (författare)
-
Mauch, Cornelia (författare)
-
Arance, Ana (författare)
-
Cognetti, Francesco (författare)
-
- Ny, Lars, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
-
Schmidt, Henrik (författare)
-
Schadendorf, Dirk (författare)
-
Gogas, Helen (författare)
-
Zoco, Jesús (författare)
-
Re, Sandra (författare)
-
Ascierto, Paolo A (författare)
-
Atkinson, Victoria (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020
- 2020
- Engelska.
-
Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 38:33, s. 3937-3946
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The CheckMate 066 trial investigated nivolumab monotherapy as first-line treatment for patients with previously untreated BRAF wild-type advanced melanoma. Five-year results are presented herein.In this multicenter, double-blind, phase III study, 418 patients with previously untreated, unresectable, stage III/IV, wild-type BRAF melanoma were randomly assigned 1:1 to receive nivolumab 3 mg/kg every 2 weeks or dacarbazine 1,000 mg/m2 every 3 weeks. The primary end point was overall survival (OS), and secondary end points included progression-free survival (PFS), objective response rate (ORR), and safety.Patients were followed for a minimum of 60 months from the last patient randomly assigned (median follow-up, 32.0 months for nivolumab and 10.9 months for dacarbazine). Five-year OS rates were 39% with nivolumab and 17% with dacarbazine; PFS rates were 28% and 3%, respectively. Five-year OS was 38% in patients randomly assigned to dacarbazine who had subsequent therapy, including nivolumab (n = 37). ORR was 42% with nivolumab and 14% with dacarbazine; among patients alive at 5 years, ORR was 81% and 39%, respectively. Of 42 patients treated with nivolumab who had a complete response (20%), 88% (37 of 42) were alive as of the 5-year analysis. Among 75 nivolumab-treated patients alive and evaluable at the 5-year analysis, 83% had not received subsequent therapy; 23% were still on study treatment, and 60% were treatment free. Safety analyses were similar to the 3-year report.Results from this 5-year analysis confirm the significant benefit of nivolumab over dacarbazine for all end points and add to the growing body of evidence supporting long-term survival with nivolumab mono-therapy. Survival is strongly associated with achieving a durable response, which can be maintained after treatment discontinuation, even without subsequent systemic therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Robert, Caroline
-
Long, Georgina V
-
Brady, Benjamin
-
Dutriaux, Caroli ...
-
Di Giacomo, Anna ...
-
Mortier, Laurent
-
visa fler...
-
Rutkowski, Piotr
-
Hassel, Jessica ...
-
McNeil, Catriona ...
-
Kalinka, Ewa Ann ...
-
Lebbé, Céleste
-
Charles, Julie
-
Hernberg, Micael ...
-
Savage, Kerry J
-
Chiarion-Sileni, ...
-
Mihalcioiu, Cata ...
-
Mauch, Cornelia
-
Arance, Ana
-
Cognetti, France ...
-
Ny, Lars, 1967
-
Schmidt, Henrik
-
Schadendorf, Dir ...
-
Gogas, Helen
-
Zoco, Jesús
-
Re, Sandra
-
Ascierto, Paolo ...
-
Atkinson, Victor ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Journal of clini ...
- Av lärosätet
-
Göteborgs universitet