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Fluorocarbons facil...
Fluorocarbons facilitate lung recruitment
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Cox, Peter N. (author)
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Frndova, Helena (author)
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- Karlsson, Ove (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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Holowka, Stephanie (author)
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Bryan, Charles A. (author)
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(creator_code:org_t)
- 2003-09-13
- 2003
- English.
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In: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 29, s. 2297-2302
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objective: "Open the lung and keep it open" is increasingly accepted as a fundamental principle for mechanical ventilation. However, it is sometimes very difficult, or impossible, to recruit the diseased lung. We questioned whether one could facilitate recruitment by using a low dose of fluorocarbon in a model previously shown to be non-recruitable by conventional sustained inflation maneuvers. Design and setting: Experimental prospective study in a university laboratory. Animals and interventions: Nine saline-lavaged rabbits subjected to prolonged large tidal volume mechanical ventilation to establish significant lung injury were randomly allocated to two groups: control [High Frequency Oscillation (HFO) alone: n=4] or 1 ml/kg fluorocarbon (FC) treated (HFO/FC: n=5) for 2+1 h (experiment 1). An additional four similarly prepared animals were treated by single-lung instillation of 0.5 ml/kg dose of fluorocarbon and underwent serial computerized tomography scans at a series of predetermined step-wise pressure increase in both lungs (experiment 2). Measurements and results: In experiment 1 there was a very significant improvement in oxygenation in HFO/FC group (PaO2 increased from 108 mmHg to 424±81 mmHg; P<0.05) while there was no significant change in the control group. In experiment 2 lung volumes were determined using three-dimensional reconstruction. The lung having fluorocarbon showed a 2.4-fold increase in lung volume at inflation pressure of 15 cmH 2O compared to the lung without fluorocarbon. Conclusions: We propose that the low equilibrium surface tension and positive spreading coefficient of fluorocarbon facilitates lung recruitment by ungluing adherent surfaces in this model of lung injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Fluorocarbon
- Lung recruitment
- Lung volume
- Surface tension
Publication and Content Type
- ref (subject category)
- art (subject category)
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