Current concepts and an alternative perspective on periodontal disease.

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Dahlén, Gunnar,1944Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology (author)

Current concepts and an alternative perspective on periodontal disease.

Article/chapterEnglish2020

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2020-08-26
Springer Science and Business Media LLC,2020

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LIBRIS-ID:oai:gup.ub.gu.se/299138
https://gup.ub.gu.se/publication/299138URI
https://doi.org/10.1186/s12903-020-01221-4DOI

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Language:English

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Subject category:for swepub-publicationtype

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Epidemiological data from countries worldwide show a consistent pattern implying that a fraction of around 10% of those over 40-50years in all populations will exhibit severe periodontitis with the potential risk of losing teeth during their life-time. The subgingival microbiota shows striking similarities between populations irrespective of disease severity and can only marginally explain the clinical pattern. It is also difficult to explain this pattern by genetic and acquired risk factors such as systemic disease (e.g. diabetes) or habits (e.g. smoking) even if they may have a confounding effect on the disease.Inflammation of the gingiva appears to be a normal and physiological response to the presence of commensal bacteria along the gingival crevice and in the dental biofilm. Over many years of exposure to the dental biofilm, the chronic inflammation in the gingiva gradually results in a loss of attachment and bone loss. Numerous laboratory and clinical studies have provided insight into the potential role of determinants that are associated with periodontitis. However, it has been difficult to relate the findings to the pattern of the distribution of the disease observed in epidemiological studies. We propose a simple and parsimonious model that considers all the multitude of potential determinants as creating effectively random noise within the dental biofilm to which the tissues react by accumulating the effects of this noise.We suggest that such a model can explain many of the epidemiological features of periodontal breakdown over time, and we discuss its clinical implications.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng

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Fejerskov, Ole (author)
Manji, Firoze (author)
Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)

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In:BMC oral health: Springer Science and Business Media LLC20:11472-6831

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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