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Search: id:"swepub:oai:gup.ub.gu.se/299281" > Evaluation of a nov...

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  • Hanes, JozefAxon Neuroscience SE (author)

Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias.

  • Article/chapterEnglish2020

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  • 2020

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  • LIBRIS-ID:oai:gup.ub.gu.se/299281
  • https://gup.ub.gu.se/publication/299281URI
  • https://doi.org/10.1212/WNL.0000000000010814DOI
  • https://lup.lub.lu.se/record/ead1c4ad-b4f5-4f38-8df0-94f6fb24a0c5URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls.We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from 3 cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy participants (n = 44).The p-tau T217 assay (cutoff 242 pg/mL) identified patients with AD with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, and 88% specificity, compared favorably with p-tau T181 ELISA (52 pg/mL), showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity, and 97% sensitivity. The assay distinguished patients with AD from age-matched healthy controls (cutoff 163 pg/mL, 98% sensitivity, 93% specificity), similarly to p-tau T181 ELISA (cutoff 60 pg/mL, 96% sensitivity, 86% specificity). In patients with AD, we found a strong correlation between p-tau T217 and p-tau T181, total tau and β-amyloid 40, but not β-amyloid 42.This study demonstrates that p-tau T217 displayed better diagnostic accuracy than p-tau T181. The data suggest that the new p-tau T217 assay has potential as an AD diagnostic test in clinical evaluation.This study provides Class III evidence that a CSF immunoassay for p-tau T217 distinguishes patients with AD from patients with other dementias and healthy controls.

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  • Kovac, AndrejAxon Neuroscience SE (author)
  • Kvartsberg, Hlin,1987Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:gu)xjohhl (author)
  • Kontsekova, EvaAxon Neuroscience SE (author)
  • Fialova, LubicaAxon Neuroscience SE (author)
  • Katina, StanislavAxon Neuroscience SE (author)
  • Kovacech, BranislavAxon Neuroscience SE (author)
  • Stevens, EvaAxon Neuroscience SE (author)
  • Hort, JakubCharles University in Prague (author)
  • Vyhnalek, MartinCharles University in Prague (author)
  • Boonkamp, LynnAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Novak, MichalAxon Neuroscience SE (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:lu)med-hiz (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
  • Scheltens, PhilipAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:lu)med-kbw (author)
  • Teunissen, Charlotte EAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Zilka, NorbertAxon Neuroscience SE (author)
  • Axon Neuroscience SEInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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  • In:Neurology95:221526-632X

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