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Evaluation of a nov...
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Hanes, JozefAxon Neuroscience SE
(author)
Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias.
- Article/chapterEnglish2020
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LIBRIS-ID:oai:gup.ub.gu.se/299281
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https://gup.ub.gu.se/publication/299281URI
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https://doi.org/10.1212/WNL.0000000000010814DOI
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https://lup.lub.lu.se/record/ead1c4ad-b4f5-4f38-8df0-94f6fb24a0c5URI
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Subject category:art swepub-publicationtype
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To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls.We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from 3 cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy participants (n = 44).The p-tau T217 assay (cutoff 242 pg/mL) identified patients with AD with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, and 88% specificity, compared favorably with p-tau T181 ELISA (52 pg/mL), showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity, and 97% sensitivity. The assay distinguished patients with AD from age-matched healthy controls (cutoff 163 pg/mL, 98% sensitivity, 93% specificity), similarly to p-tau T181 ELISA (cutoff 60 pg/mL, 96% sensitivity, 86% specificity). In patients with AD, we found a strong correlation between p-tau T217 and p-tau T181, total tau and β-amyloid 40, but not β-amyloid 42.This study demonstrates that p-tau T217 displayed better diagnostic accuracy than p-tau T181. The data suggest that the new p-tau T217 assay has potential as an AD diagnostic test in clinical evaluation.This study provides Class III evidence that a CSF immunoassay for p-tau T217 distinguishes patients with AD from patients with other dementias and healthy controls.
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Kovac, AndrejAxon Neuroscience SE
(author)
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Kvartsberg, Hlin,1987Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:gu)xjohhl
(author)
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Kontsekova, EvaAxon Neuroscience SE
(author)
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Fialova, LubicaAxon Neuroscience SE
(author)
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Katina, StanislavAxon Neuroscience SE
(author)
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Kovacech, BranislavAxon Neuroscience SE
(author)
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Stevens, EvaAxon Neuroscience SE
(author)
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Hort, JakubCharles University in Prague
(author)
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Vyhnalek, MartinCharles University in Prague
(author)
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Boonkamp, LynnAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Novak, MichalAxon Neuroscience SE
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:lu)med-hiz
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn
(author)
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Scheltens, PhilipAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital(Swepub:lu)med-kbw
(author)
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Teunissen, Charlotte EAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Zilka, NorbertAxon Neuroscience SE
(author)
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Axon Neuroscience SEInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Neurology95:221526-632X
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Hanes, Jozef
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Kovac, Andrej
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Kvartsberg, Hlin ...
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Kontsekova, Eva
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Fialova, Lubica
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Katina, Stanisla ...
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Kovacech, Branis ...
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Stevens, Eva
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Hort, Jakub
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Vyhnalek, Martin
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Boonkamp, Lynn
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Novak, Michal
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Zetterberg, Henr ...
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Hansson, Oskar
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Scheltens, Phili ...
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Blennow, Kaj, 19 ...
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Teunissen, Charl ...
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Zilka, Norbert
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