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  • Modvig, SCopenhagen University Hospital,Vilnius University,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Vilnius Univ Hosp, Santaros Klin, Hematol Oncol & Transfus Med Ctr, Vilnius, Lithuania. (author)

Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-12-14
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/299424
  • https://gup.ub.gu.se/publication/299424URI
  • https://doi.org/10.1038/s41375-020-01100-5DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178333URI
  • https://lup.lub.lu.se/record/7bab7e42-4df7-4f74-8d4f-140962a25921URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454517URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO ALL2008 protocol. When no informative FCM-marker was available, risk stratification was based on real-time quantitative PCR. An informative FCM-marker was found in 96.2% and only two patients (0.14%) had non-informative FCM and non-informative PCR-markers. The overall 5-year event-free survival was 86.1% with a cumulative incidence of relapse (CIR5y) of 9.5%. FCM-MRD levels on days 15 (HzR 4.0, p<0.0001), 29 (HzR 2.7, p<0.0001), and 79 (HzR 3.5, p<0.0001) associated with hazard of relapse adjusted for age, cytogenetics, and WBC. The early (day 15) response associated with CIR5y adjusted for day 29 FCM-MRD, with higher levels in adults (median 2.4×10-2 versus 5.2×10-3, p<0.0001). Undetectable FCM- and/or PCR-MRD on day 29 identified patients with a very good outcome (CIR5y=3.2%). For patients who did not undergo transplantation, day 79 FCM-MRD>10-4 associated with a CIR5y=22.1%. In conclusion, FCM-MRD performed in a multicenter setting is a clinically useful method for MRD-based treatment stratification in BCP-ALL.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hallböök, HeleneUppsala universitet,Uppsala University,Copenhagen University Hospital,Oslo university hospital,Hematologi,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Oslo Univ Hosp, Dept Pathol, Lab Mol Pathol, Oslo, Norway.(Swepub:uu)helehall (author)
  • Madsen, H OUmeå University,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden. (author)
  • Siitonen, SUniversity of Helsinki,University of Copenhagen,Univ Helsinki, Clin Chem, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.,Univ Copenhagen, Sect Biostat, Copenhagen, Denmark. (author)
  • Rosthøj, S (author)
  • Tierens, AUniversity of Toronto,Oslo university hospital,Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.;Univ Hosp Oslo, Dept Pathol, Oslo, Norway. (author)
  • Juvonen, VUniversity of Turku,Univ Turku, Dept Clin Chem, Turku, Finland.;Univ Turku, Lab Div, Turku, Finland.;Turku Univ Hosp, Turku, Finland. (author)
  • Osnes, L T NOslo university hospital,Herlev Hospital,Oslo Univ Hosp, Dept Immunol, Oslo, Norway.,Herlev Univ Hosp, Dept Hematol, Herlev, Denmark. (author)
  • Vålerhaugen, H (author)
  • Hultdin, MagnusUmeå universitet,Patologi(Swepub:umu)magn0001 (author)
  • Matuzeviciene, RVilnius University,Vilnius Univ, Inst Biomed Sci, Fac Med, Dept Physiol Biochem Microbiol & Lab Med, Vilnius, Lithuania.;Vilnius Univ Hosp, Santaros Klin, Ctr Lab Med, Vilnius, Lithuania. (author)
  • Stoskus, M (author)
  • Ehinger, M.Lund University,Lunds universitet,Uppsala University,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Clin Genet & Pathol, Lund, Sweden.;Lund Univ, Dept Clin Sci Oncol & Pathol, Lund, Sweden.(Swepub:lu)efor-meh (author)
  • Lilleorg, ANorth Estonia Medical Centre,North Estonia Med Ctr, Dept Clin Immunol, Tallinn, Estonia. (author)
  • Ehinger, M (author)
  • Norén-Nyström, UlrikaUmeå University,Umeå universitet,Pediatrik,Umeå Univ, Dept Clin Sci, Pediat, Umeå, Sweden.(Swepub:umu)kagr0007 (author)
  • Toft, N (author)
  • Taskinen, MHelsinki University Central Hospital,Helsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland. (author)
  • Jónsson, O GNational University Hospital of Iceland,Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland. (author)
  • Pruunsild, KTallinn Children's Hospital,Tallinn Childrens Hosp, Tallinn, Estonia. (author)
  • Vaitkeviciene, GVilnius University,Vilnius Univ Hosp, Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania. (author)
  • Vettenranta, KUniversity of Helsinki,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Childrens Hosp, Helsinki, Finland. (author)
  • Lund, BSt. Olav’s University Hospital,St Olavs Univ Hosp, Dept Pediat, Trondheim, Norway.;NTNU, Dept Clin & Mol Med, Trondheim, Norway. (author)
  • Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.(Swepub:gu)xabrjo (author)
  • Porwit, A.Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Fac Med, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.(Swepub:lu)an6742po (author)
  • Schmiegelow, KCopenhagen University Hospital,Copenhagen Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Med, Copenhagen, Denmark. (author)
  • Marquart, H V (author)
  • Marincevic, Millaray,1983-Uppsala universitet,Klinisk och experimentell patologi(Swepub:uu)milma629 (author)
  • Copenhagen University HospitalVilnius University (creator_code:org_t)

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