Search: (hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Kardiologi)) pers:(James Stefan 1964) lar1:(liu) >
Mortality with Pacl...
Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease.
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- Nordanstig, Joakim (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Gothenburg Univ, Sweden
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- James, Stefan, 1964- (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Sweden
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- Andersson, Manne (author)
- Linköpings universitet,Linköping University,Ryhov County Hospital, Jönköping,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Cty Hosp Ryhov, Sweden
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- Andersson, Mattias (author)
- Sunderby Hospital,Sunderby Hosp, Sweden
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- Danielsson, Peter (author)
- Halmstad County Hospital,Halland Hosp, Sweden
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- Gillgren, Peter (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,Karolinska Inst, Sweden; Soder Sjukhuset, Sweden
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- Delle, Martin (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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- Engström, Jan (author)
- Karolinska University Hospital,Karolinska Univ Hosp, Sweden
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- Fransson, Torbjörn (author)
- Skåne University Hospital,Skane Univ Hosp, Sweden
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- Hamoud, Maher (author)
- Skaraborg Hospital,Skaraborgs Hosp, Sweden
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- Hilbertson, Anna (author)
- Central Hospital Kristianstad,Kristianstad Hosp, Sweden
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- Johansson, Patrik (author)
- Växjö Central Hospital,Vaxjo Hosp, Sweden
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- Karlsson, Lars (author)
- Gävle Hospital,Gothenburg Univ, Sweden; Gavle Cent Hosp, Sweden
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- Kragsterman, Björn (author)
- Uppsala University,Uppsala universitet,Kärlkirurgi,Uppsala Univ, Sweden
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- Lindgren, Hans (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Helsingborg Hospital,Fac Med, Sweden; Lund Univ, Sweden; Helsingborg Hosp, Sweden
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- Ludwigs, Karin (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,South Elfsborg Hospital,Sodra Alvsborg Hosp, Sweden
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- Mellander, Stefan (author)
- NU Hospital Group,NU Hosp Grp, Sweden
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- Nyman, Niklas (author)
- Stockholm South General Hospital,Soder Sjukhuset, Sweden
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- Renlund, Henrik, 1979- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Sigvant, Birgitta (author)
- Uppsala University,Uppsala universitet,Kärlkirurgi,Karlstad Hospital,Uppsala Univ, Sweden; Karlstad Cent Hosp, Sweden
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- Skoog, Per (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Gothenburg Univ, Sweden
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- Starck, Joachim (author)
- Västervik Hospital,Lund Univ, Sweden; Vastervik Hosp, Sweden
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- Tegler, Gustaf, 1968- (author)
- Uppsala University,Uppsala universitet,Kärlkirurgi,Uppsala Univ, Sweden
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- Toivola, Asko (author)
- Örebro University Hospital,Orebro Univ Hosp, Sweden
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- Truedson, Maria (author)
- Umeå University,Umeå universitet,Diagnostisk radiologi,Umea Univ, Sweden
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- Wahlgren, Carl-Magnus (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Wallinder, Jonas (author)
- Sundsvall Hospital,Sundsvall Dist Hosp, Sweden
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- Öjersjö, Andreas (author)
- Kalmar County Hospital,Kalmar Hosp, Sweden
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- Falkenberg, Mårten, 1959 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Gothenburg Univ, Sweden
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(creator_code:org_t)
- Massachusetts Medical Society, 2020
- 2020
- English.
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In: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 383, s. 2538-46
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Abstract
Subject headings
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- The results of a recent meta-analysis aroused concern about an increased risk of death associated with the use of paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.We conducted an unplanned interim analysis of data from a multicenter, randomized, open-label, registry-based clinical trial. At the time of the analysis, 2289 patients had been randomly assigned to treatment with drug-coated devices (the drug-coated-device group, 1149 patients) or treatment with uncoated devices (the uncoated-device group, 1140 patients). Randomization was stratified according to disease severity on the basis of whether patients had chronic limb-threatening ischemia (1480 patients) or intermittent claudication (809 patients). The single end point for this interim analysis was all-cause mortality.No patients were lost to follow-up. Paclitaxel was used as the coating agent for all the drug-coated devices. During a mean follow-up of 2.49 years, 574 patients died, including 293 patients (25.5%) in the drug-coated-device group and 281 patients (24.6%) in the uncoated-device group (hazard ratio, 1.06; 95% confidence interval, 0.92 to 1.22). At 1 year, all-cause mortality was 10.2% (117 patients) in the drug-coated-device group and 9.9% (113 patients) in the uncoated-device group. During the entire follow-up period, there was no significant difference in the incidence of death between the treatment groups among patients with chronic limb-threatening ischemia (33.4% [249 patients] in the drug-coated-device group and 33.1% [243 patients] in the uncoated-device group) or among those with intermittent claudication (10.9% [44 patients] and 9.4% [38 patients], respectively).In this randomized trial in which patients with peripheral artery disease received treatment with paclitaxel-coated or uncoated endovascular devices, the results of an unplanned interim analysis of all-cause mortality did not show a difference between the groups in the incidence of death during 1 to 4 years of follow-up. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT02051088.).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nordanstig, Joak ...
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James, Stefan, 1 ...
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Andersson, Manne
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Andersson, Matti ...
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Danielsson, Pete ...
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Gillgren, Peter
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Delle, Martin
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Engström, Jan
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Fransson, Torbjö ...
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Hamoud, Maher
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Hilbertson, Anna
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Johansson, Patri ...
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Karlsson, Lars
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Kragsterman, Bjö ...
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Lindgren, Hans
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Ludwigs, Karin
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Mellander, Stefa ...
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Nyman, Niklas
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Renlund, Henrik, ...
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Sigvant, Birgitt ...
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Skoog, Per
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Starck, Joachim
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Tegler, Gustaf, ...
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Toivola, Asko
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Truedson, Maria
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Wahlgren, Carl-M ...
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Wallinder, Jonas
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Öjersjö, Andreas
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Falkenberg, Mårt ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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- By the university
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University of Gothenburg
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Umeå University
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Uppsala University
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Lund University
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Karolinska Institutet
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Linköping University