A Primer on Dose-Response Data Modeling in Radiation Therapy.

An overview of common approaches used to assess a dose response for radiation therapy-associated endpoints is presented, using lung toxicity data sets analyzed as a part of the High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic effort as an example. Each component presented (eg, data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction) is addressed using established approaches. Specifically, the maximum likelihood method was used to calculate best parameter values of the commonly used logistic model, the profile-likelihood to calculate confidence intervals on model parameters, and the likelihood ratio to determine whether the observed data fit is statistically significant. The bootstrap method was used to calculate confidence intervals for model predictions. Correlated behavior of model parameters and implication for interpreting dose response are discussed.

Marks, Lawrence B (author)
Grimm, Jimm (author)
Jackson, Andrew (author)
Milano, Michael T (author)
Hattangadi-Gluth, Jona A (author)
Huynh-Le, Minh-Phuong (author)
Pettersson, Niclas,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences(Swepub:gu)xpettn (author)
Yorke, Ellen (author)
El Naqa, Issam (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap (creator_code:org_t)

In:International journal of radiation oncology, biology, physics: Elsevier BV110:1, s. 11-201879-355X0360-3016

By the author/editor: Moiseenko, Vital ...; Marks, Lawrence ...; Grimm, Jimm; Jackson, Andrew; Milano, Michael ...; Hattangadi-Gluth ...; show more...; Huynh-Le, Minh-P ...; Pettersson, Nicl ...; Yorke, Ellen; El Naqa, Issam; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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