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  • Gio-Batta, MonicaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg (author)

Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema.

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-12-31
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/300189
  • https://gup.ub.gu.se/publication/300189URI
  • https://doi.org/10.1038/s41598-020-79737-6DOI
  • https://research.chalmers.se/publication/521704URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145646681URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Children growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected from 28 farming and 37 control children over the first 3years of life using gas chromatography. Data on diet and other host factors were recorded and allergy was diagnosed at 8years of age. Among all children, median propionic and butyric acid concentration increased over the first 3years, and longer SCFAs typically appeared by 1year of age. Farm children had higher levels of iso-butyric, iso-valeric and valeric acid at 3years of age than rural controls. In addition, children with elder siblings had higher levels of valeric acid at 3years of age, and dietary factors also affected SCFA pattern. High levels of valeric acid at 3years of age were associated with low rate of eczema at 8years of age. The fecal SCFA pattern in farm children suggests a more rapid maturation of the gut microbiota. Valeric acid or associated microbes may have protective potential against eczema.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sjöberg, FeiGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xsjofe (author)
  • Jonsson, Karin,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)jkarin (author)
  • Barman, Malin,1983Chalmers tekniska högskola,Chalmers University of Technology,Karolinska Institutet(Swepub:cth)barman (author)
  • Lundell, Anna-Carin,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg(Swepub:gu)xaanni (author)
  • Adlerberth, Ingegerd,1959Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xadlin (author)
  • Hesselmar, Bill,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg(Swepub:gu)xhessb (author)
  • Sandberg, Ann-Sofie,1951Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)annsandb (author)
  • Wold, Agnes E,1955Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg(Swepub:gu)xwolag (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

Related titles

  • In:Scientific reports: Springer Science and Business Media LLC10:12045-2322

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