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Sökning: L773:1462 0324 OR L773:1462 0332 OR L773:1310 0505 > Negative associatio...

  • Wadström, KarinLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital (författare)

Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-02
  • Oxford University Press (OUP),2020

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/301099
  • https://gup.ub.gu.se/publication/301099URI
  • https://doi.org/10.1093/rheumatology/keaa080DOI
  • https://lup.lub.lu.se/record/e6439381-95be-4457-bfe5-2afb4a051dcdURI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmo Preventive Medicine Project; N = 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results. A total of 76 cases with a confirmed incident diagnosis of GCA (61 % female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (s.D. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (s.D. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (s.D. overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. Conclusion. Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jacobsson, Lennart T. H.,1954University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:lu)orto-lja (författare)
  • Mohammad, Aladdin J.Skåne University Hospital,University of Cambridge(Swepub:lu)reum-amo (författare)
  • Warrington, K. J.Mayo Clinic Minnesota (författare)
  • Matteson, E. L.Mayo Clinic Minnesota (författare)
  • Turesson, CarlLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ctn (författare)
  • Internmedicin - epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Rheumatology: Oxford University Press (OUP)59:11, s. 3229-32361462-03241462-03321310-0505

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