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Negative associatio...
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Wadström, KarinLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
(författare)
Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-04-02
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Oxford University Press (OUP),2020
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/301099
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https://gup.ub.gu.se/publication/301099URI
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https://doi.org/10.1093/rheumatology/keaa080DOI
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https://lup.lub.lu.se/record/e6439381-95be-4457-bfe5-2afb4a051dcdURI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmo Preventive Medicine Project; N = 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results. A total of 76 cases with a confirmed incident diagnosis of GCA (61 % female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (s.D. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (s.D. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (s.D. overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. Conclusion. Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jacobsson, Lennart T. H.,1954University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:lu)orto-lja
(författare)
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Mohammad, Aladdin J.Skåne University Hospital,University of Cambridge(Swepub:lu)reum-amo
(författare)
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Warrington, K. J.Mayo Clinic Minnesota
(författare)
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Matteson, E. L.Mayo Clinic Minnesota
(författare)
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Turesson, CarlLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ctn
(författare)
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Internmedicin - epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Rheumatology: Oxford University Press (OUP)59:11, s. 3229-32361462-03241462-03321310-0505
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