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Antireflux surgery ...
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study
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- Yanes, M. (författare)
- Karolinska Institutet
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- Santoni, G. (författare)
- Karolinska Institutet
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- Maret-Ouda, J. (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Upper Gastrointestinal Surg, Stockholm, Sweden.
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- Ness-Jensen, E. (författare)
- Karolinska Institutet
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- Färkkilä, M. (författare)
- Univ Helsinki, Clin Gastroenterol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Lynge, E. (författare)
- Univ Copenhagen, Nykobing Falster Hosp, Copenhagen, Denmark.
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- Nwaru, Bright I, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Krefting Research Centre,Univ Gothenburg, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
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- Pukkala, E. (författare)
- Finnish Canc Registry, Inst Stat & Epidemiol Canc Res, Helsinki, Finland.;Tampere Univ, Fac Social Sci, Tampere, Finland.
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- Romundstad, P. (författare)
- Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, NTNU, Trondheim, Norway.
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- Tryggvadóttir, L. (författare)
- Iceland Canc Soc, Icelandic Canc Registry, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- von Euler-Chelpin, M. (författare)
- Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
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- Lagergren, J. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 138, s. 80-88
- Relaterad länk:
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http://www.ejcancer....
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis that antireflux surgery decreases the risk of small cell carcinoma, squamous cell carcinoma and adenocarcinoma of the lung differently depending on their location in relation to micro-aspiration. Methods: Population-based cohort study including patients having undergone antireflux surgery during 1980–2014 in Denmark, Finland, Iceland, Norway or Sweden. Patients having undergone antireflux surgery were compared with two groups: 1) the corresponding background population, by calculating standardised incidence ratios (SIRs) with 95% confidence intervals (CIs) and 2) non-operated GERD-patients, by calculating hazard ratios (HRs) with 95% CIs using multivariable Cox regression with adjustment for sex, age, calendar period, country, chronic obstructive pulmonary disease and obesity diagnosis or type 2 diabetes. Results: Among all 812,617 GERD-patients, 46,996 (5.8%) had undergone antireflux surgery. The SIRs were statistically significantly decreased for small cell carcinoma (SIR = 0.57, 95% CI 0.41–0.77) and squamous cell carcinoma (SIR = 0.75, 95% CI 0.60–0.92), but not for adenocarcinoma of the lung (SIR = 0.90, 95% CI 0.76–1.06). The HRs were also below unity for small cell carcinoma (HR = 0.63, 95% CI 0.44–0.90) and squamous cell carcinoma (HR = 0.80, 95% CI 0.62–1.03), but not for adenocarcinoma of the lung (HR = 1.03, 95% CI 0.84–1.26). Analyses restricted to patients with objective GERD (reflux oesophagitis or Barrett's oesophagus) showed similar results. Conclusions: This all-Nordic study indicates that patients who undergo antireflux surgery are at decreased risk of small cell carcinoma and squamous cell carcinoma of the lung, but not of adenocarcinoma of the lung. © 2020 The Author(s)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Bronchus
- Fundoplication
- GERD
- GORD
- Neoplasm
- Nissen
- Pulmonary
- adult
- age
- aged
- antireflux operation
- Article
- cancer risk
- chronic obstructive lung disease
- cohort analysis
- confidence interval
- controlled study
- Denmark
- female
- Finland
- gastroesophageal reflux
- hazard ratio
- histopathology
- human
- human tissue
- Iceland
- lung adenocarcinoma
- lung aspiration
- major clinical study
- male
- middle aged
- non insulin dependent diabetes mellitus
- Norway
- obesity
- population research
- priority journal
- proportional hazards model
- sex
- small cell lung cancer
- squamous cell lung carcinoma
- statistically significant result
- Sweden
- Neoplasm
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yanes, M.
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Santoni, G.
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Maret-Ouda, J.
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Ness-Jensen, E.
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Färkkilä, M.
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Lynge, E.
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visa fler...
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Nwaru, Bright I, ...
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Pukkala, E.
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Romundstad, P.
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Tryggvadóttir, L ...
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von Euler-Chelpi ...
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Lagergren, J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet