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  • Akerblom, H.Department of Ophthalmology, Region Västmanland, Västerås, Sweden,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden. (författare)

Association of Gastric Bypass Surgery With Risk of Developing Diabetic Retinopathy Among Patients With Obesity and Type 2 Diabetes in Sweden: An Observational Study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • American Medical Association (AMA),2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/301520
  • https://gup.ub.gu.se/publication/301520URI
  • https://doi.org/10.1001/jamaophthalmol.2020.5892DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88531URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450110URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • IMPORTANCE Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. OBJECTIVE To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have not undergone GBP. DESIGN, SETTING, AND PARTICIPANTS Data from 2 nationwide registers in Sweden, the Scandinavian Obesity Surgery Registry and the National Diabetes Register, were used for this cohort study. A total of 5321 patients with diabetes from the Scandinavian Obesity Surgery Registry who had undergone GBP from January 1, 2007, to December 31, 2013, were matched with 5321 patients with diabetes from the National Diabetes Register who had not undergone GBP, based on sex, age, body mass index (BMI), and calendar time (2007-2013). Follow-up data were obtained until December 31, 2015. Statistical analysis was performed from October 5, 2018, to September 30, 2019. EXPOSURE Gastric bypass surgery. MAIN OUTCOMES AND MEASURES Incidence of new DR and other diabetic ocular complications. RESULTS The study population consisted of 5321 patients who had undergone GBP (3223 women [60.6%]; mean [SD] age, 49.0 [9.5] years) and 5321 matched controls (3395 women [63.8%]; mean [SD] age, 47.1 [11.5] years). Mean (SD) follow-up was 4.5 (1.6) years. The mean (SD) BMI and hemoglobin A1c concentration at baseline were 42.0 (5.7) and 7.6%(1.5%), respectively, in the GBP group and 40.9 (7.3) and 7.5%(1.5%), respectively, in the control group. The mean (SD) duration of diabetes was 6.8 (6.3) years in the GBP group and 6.4 (6.4) years in the control group. The risk for new DR was reduced in the patients who underwent GBP (hazard ratio, 0.62 [95% CI, 0.49-0.78]; P <.001). The dominant risk factors for development of DR at baseline were diabetes duration, hemoglobin A1c concentration, use of insulin, glomerular filtration rate, and BMI. CONCLUSIONS AND RELEVANCE This nationwide matched cohort study suggests that there is a reduced risk of developing new DR associated with GBP, and no evidence of an increased risk of developing DR that threatened sight or required treatment. (c) 2021 American Medical Association. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Franzén, Stefan,1967Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,National Diabetes Register, Center of Registers, Gothenburg, Sweden; Health Metrics Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Hlth Metr Unit, Gothenburg, Sweden.(Swepub:gu)xfrast (författare)
  • Zhou, C. D.National Diabetes Register, Center of Registers, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden. (författare)
  • Moren, A.Department of Ophthalmology, Region Västmanland, Västerås, Sweden,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden. (författare)
  • Ottosson, Johan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.(Swepub:oru)jhon (författare)
  • Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (författare)
  • Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xelibj (författare)
  • Svensson, Ann-Marie,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,National Diabetes Register, Center of Registers, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xsannh (författare)
  • Granstam, Elisabet,1963-Uppsala universitet,Centrum för klinisk forskning, Västerås,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden.(Swepub:uu)elisgran (författare)
  • Department of Ophthalmology, Region Västmanland, Västerås, SwedenReg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Jama Ophthalmology: American Medical Association (AMA)139:2, s. 200-2052168-61652168-6173

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