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Hematopoietic cell transplant in pediatric acute myeloid leukemia after similar upfront therapy; a comparison of conditioning regimens
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- Versluys, A. B. (author)
- Univ Med Ctr Utrecht, Princess Maxima Ctr Pediat Oncol, Dept Pediat Blood & Marrow Transplantat, Utrecht, Netherlands.,Ghent Univ Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Ghent, Belgium.
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- Boelens, J. J. (author)
- Univ Med Ctr Utrecht, Princess Maxima Ctr Pediat Oncol, Dept Pediat Blood & Marrow Transplantat, Utrecht, Netherlands.;Mem Sloan Kettering, Dept Pediat Stem Cell Transplantat & Cellular The, New York, NY USA.
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- Pronk, C. (author)
- Skane Univ Hosp, Dept Pediat Oncol & Hematol, Lund, Sweden.
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- Lankester, A. (author)
- Leiden Univ, Med Ctr, Willem Alexander Childrens Hosp, Dept Pediat, Leiden, Netherlands.
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Bordon, V. (author)
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- Buchner, J. (author)
- Oslo Univ Hosp, Dept Pediat Hematol & Oncol, Oslo, Norway.
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- Ifversen, M. (author)
- Copenhagen Univ Hosp, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.
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- Jackmann, Natalja (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Sundin, M. (author)
- Karolinska Institutet
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- Vettenranta, K. (author)
- Univ Helsinki, Helsinki, Finland.;Univ Helsinki, Childrens Hosp, Helsinki, Finland.
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
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- Mellgren, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
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Univ Med Ctr Utrecht, Princess Maxima Ctr Pediat Oncol, Dept Pediat Blood & Marrow Transplantat, Utrecht, Netherlands Ghent Univ Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Ghent, Belgium. (creator_code:org_t)
- 2021-01-19
- 2021
- English.
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In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 56:6, s. 1426-1432
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The impact of conditioning regimen prior to hematopoietic cell transplant (HCT) in pediatric AML-patients is not well studied. We retrospectively analyzed the impact of Busulfan-Cyclophosphamide (BuCy), Busulfan-Cyclophosphamide-Melphalan (BuCyMel) and Clofarabine-Fludarabine-Busulfan (CloFluBu) in pediatric AML-patients, with similar upfront leukemia treatment (NOPHO-DBHconsortium), receiving an HCT between 2010 and 2015. Outcomes of interest were LFS, relapse, TRM and GvHD. 103 patients were included; 30 received BuCy, 37 BuCyMel, and 36 CloFluBu. The 5-years LFS was 43.3% (SE +/- 9.0) in the BuCy group, 59.2 % (SE +/- 8.1) after BuCyMel, and 66.7 % (SE +/- 7.9) after CloFluBu. Multivariable Cox regression analysis showed a trend to lower LFS after BuCy compared to CloFluBu (p = 0.07). BuCy was associated with a higher relapse incidence compared to the other regimens (p = 0.06). Younger age was a predictor for relapse (p = 0.02). A strong correlation between Busulfan Therapeutic Drug Monitoring (TDM) and lower incidence of aGvHD (p < 0.001) was found. In conclusion, LFS after BuCyMel and CloFluBu was comparable, lower LFS was found after BuCy, due to higher relapse incidence. CloFluBu was associated with lower incidence of aGvHD, suggesting lower toxicity with this type of conditioning. This finding is also explained by the impact of Busulfan monitoring.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- bone-marrow-transplantation
- busulfan
- clofarabine
- children
- melphalan
- cyclophosphamide
- fludarabine
- efficacy
- outcomes
- impact
- Biophysics
- Oncology
- Hematology
- Immunology
- Transplantation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Versluys, A. B.
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Boelens, J. J.
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Pronk, C.
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Lankester, A.
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Bordon, V.
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Buchner, J.
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show more...
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Ifversen, M.
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Jackmann, Natalj ...
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Sundin, M.
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Vettenranta, K.
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Abrahamsson, Jon ...
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Mellgren, Karin, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet