SwePub
Sök i LIBRIS databas

  Utökad sökning

hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Gastroenterologi)
 

Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Gastroenterologi) > (2020-2023) > Morbidity, risk of ...

  • Hagstrom, H.Karolinska Institutet (författare)

Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-01-26
  • Wiley,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/302084
  • https://gup.ub.gu.se/publication/302084URI
  • https://doi.org/10.1111/liv.14792DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88542URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180493URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173467URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450001URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145726640URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Stockholm Count Council  Swedish Gastrointestinal Foundation  Tore Nilssons Foundation for medical research  Ruth and Richard Julin Foundation  Stockholm County Council K2017-4579 ALF LS 2019-0064Center for innovative medicine CIMED 20180889
  • Funding Agencies|Stockholm Count Council; Swedish Gastrointestinal Foundation; Tore Nilssons Foundation for medical research; Ruth and Richard Julin Foundation; Stockholm County CouncilStockholm County Council [K2017-4579, ALF LS 2019-0064]; Center for innovative medicine [CIMED 20180889]; Swedish Cancer SocietySwedish Cancer Society [170690]
  • Background & Aims Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations. Methods We identified 3645 patients with a homozygous p.C282Y (62%) or a compound heterozygous p.C282Y/p.H63D (38%) mutation from eight centres in Sweden between 1997 and 2017. These were matched 1:10 by age, sex and county of residence to reference individuals from the general population. We ascertained incident outcomes until the end of 2017 by linkage to national registers. Studied outcomes were HH, cirrhosis, hepatocellular carcinoma (HCC), breast cancer (in women), colorectal cancer, type 1 and 2 diabetes, hypothyroidism, Parkinson's disease and mortality. Cox proportional hazards regression was used to estimate hazard ratios for these outcomes. Results Median age at diagnosis was 52 years, 44% were females. During a mean follow-up of 7.9 years, we found an increased risk for HCC, HH, cirrhosis, type 2 diabetes, osteoarthritis and death. Excess mortality was only seen in men. No increased risk was seen for colorectal or breast cancer. Liver-related outcomes were rare, with a cumulative incidence of HFE mutation carriers in a university hospital setting had an increased risk for mortality in men, along with increased risks of cirrhosis, HCC, diabetes type 2, and osteoarthritis. In general, the absolute risk for adverse outcomes was low and no increased risk for colon or breast cancer was observed.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ndegwa, N.Karolinska Institutet (författare)
  • Jalmeus, M.Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med, Huddinge, Sweden. (författare)
  • Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Linköping Univ, Div Diagnost & Specialist Med, Dept Hlth Med & Caring Sci, Linköping, Sweden.(Swepub:liu)matek92 (författare)
  • Posserud, Iris,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med & Clin Nutr, Gothenburg, Sweden. (författare)
  • Rorsman, Fredrik,Docent,1960-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)fredrikr (författare)
  • Nyhlin, Nils,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.(Swepub:oru)nnn (författare)
  • Klintman, D.Department of Gastroenterology and Hepatology, Skåne University Hospital, Lund and Malmö, Sweden,Skane Univ Hosp, Dept Gastroenterol & Hepatol, Malmö, Sweden. (författare)
  • Werner, MårtenUmeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Med, Umeå, Sweden.(Swepub:umu)manwer04 (författare)
  • Marschall, Hanns-Ulrich,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xmarsh (författare)
  • Askling, J.Karolinska Institutet (författare)
  • Stal, P.Karolinska Institutet (författare)
  • Karolinska InstitutetDepartment of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Liver International: Wiley41:3, s. 545-5531478-32231478-3231

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy