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Inflammatory hallma...
Inflammatory hallmarks of lesser prominence in psoriatic arthritis patients starting biologics: a Nordic population-based cohort study
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- Hansen, R. L. (author)
- Copenhagen University Hospital
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- Jorgensen, T. S. (author)
- Copenhagen University Hospital
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- Dreyer, L. (author)
- Aalborg University Hospital,Copenhagen University Hospital
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- Hetland, M. L. (author)
- Copenhagen University Hospital,University of Copenhagen
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- Glintborg, B. (author)
- Copenhagen University Hospital,University of Copenhagen
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- Askling, J. (author)
- Karolinska Institute,Karolinska Institutet
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- Di Giuseppe, D. (author)
- Karolinska Institute,Karolinska Institutet
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- Jacobsson, Lennart T. H., 1954 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Wallman, Johan K. (author)
- Lund University,Lunds universitet,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Nordstrom, D. (author)
- Helsinki University Central Hospital
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Aaltonen, K. (author)
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- Kristianslund, E. K. (author)
- Diakonhjemmet Hospital
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- Kvien, T. K. (author)
- Diakonhjemmet Hospital
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- Provan, S. A. (author)
- Diakonhjemmet Hospital
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- Gudbjornsson, B. (author)
- National University Hospital of Iceland
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- Love, T. J. (author)
- University of Iceland
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- Kristensen, L. E. (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2020-06-27
- 2021
- English.
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In: Rheumatology. - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 60:1, s. 140-146
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Abstract
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- Objectives. To assess secular trends in baseline characteristics of PsA patients initiating their first or subsequent biologic DMARD (bDMARD) therapy and to explore prescription patterns and treatment rates of bDMARDs from 2006 to 2017 in the Nordic countries. Methods. PsA patients registered in the Nordic rheumatology registries initiating any treatment with bDMARDs were identified. The bDMARDs were grouped as original TNF inhibitor [TNFi; adalimumab (ADA), etanercept (ETN) and infliximab (IFX)]; certolizumab pegol (CZP) and golimumab (GOL); biosimilars and ustekinumab, based on the date of release. Baseline characteristics were compared for the five countries, supplemented by secular trends with R-2 calculations and point prevalence of bDMARD treatment. Results. A total of 18 089 patients were identified (Denmark, 4361; Iceland, 449; Norway, 1948; Finland, 1069; Sweden, 10 262). A total of 54% of the patients were female, 34.3% of patients initiated an original TNFi, 8% CZP and GOL, 7.5% biosimilars and 0.3% ustekinumab as a first-line bDMARD. Subsequent bDMARDs were 25.2% original TNFi, 9% CZP and GOL, 12% biosimilars and 2.1% ustekinumab. From 2015 through 2017 there was a rapid uptake of biosimilars. The total of first-line bDMARD initiators with lower disease activity increased from 2006 to 2017, where an R2 close to 1 showed a strong association. Conclusion. Across the Nordic countries, the number of prescribed bDMARDs increased from 2006 to 2017, indicating a previously unmet need for bDMARDs in the PsA population. In recent years, PsA patients have initiated bDMARDs with lower disease activity compared with previous years, suggesting that bDMARDs are initiated in patients with a less active inflammatory phenotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- psoriatic arthritis
- bDMARDs
- prescription patterns
- international
- collaborations
- secular trends of inflammatory hallmarks
- antitumor necrosis factor
- treatment recommendations
- eular
- recommendations
- therapy
- management
- inhibitor
- efficacy
- Rheumatology
- international collaborations
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hansen, R. L.
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Jorgensen, T. S.
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Dreyer, L.
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Hetland, M. L.
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Glintborg, B.
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Askling, J.
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show more...
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Di Giuseppe, D.
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Jacobsson, Lenna ...
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Wallman, Johan K ...
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Nordstrom, D.
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Aaltonen, K.
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Kristianslund, E ...
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Kvien, T. K.
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Provan, S. A.
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Gudbjornsson, B.
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Love, T. J.
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Kristensen, L. E ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Rheumatology
- By the university
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University of Gothenburg
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Karolinska Institutet
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Lund University