Search: (WFRF:(Gailus Durner V.)) >
Deciphering the pla...
Deciphering the plasma proteome of type 2 diabetes
-
Elhadad, M. A. (author)
-
Jonasson, C. (author)
-
Huth, C. (author)
-
show more...
-
Wilson, R. (author)
-
Gieger, C. (author)
-
Matias, P. (author)
-
Grallert, H. (author)
-
Graumann, J. (author)
-
Gailus-Durner, V. (author)
-
Rathmann, W. (author)
-
Toerne, C. V. (author)
-
Hauck, S. M. (author)
-
Koenig, W. (author)
-
Sinner, M. F. (author)
-
- Oprea, Tudor I (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Suhre, K. (author)
-
Thorand, B. (author)
-
Hveem, K. (author)
-
Peters, A. (author)
-
Waldenberger, M. (author)
-
show less...
-
(creator_code:org_t)
- 2020-09-14
- 2020
- English.
-
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2766-2778
- Related links:
-
https://diabetes.dia...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1,000 plasma proteins in the Cooperative Health Research in the Region of Augsburg (KORA) F4 cohort (n = 993, 110 cases), with subsequent replication in the third wave of the Nord-Trøndelag Health Study (HUNT3) cohort (n = 940, 149 cases). We computed logistic regression models adjusted for age, sex, BMI, smoking status, and hypertension. Addition-ally, we investigated associations with incident type 2 diabetes and performed two-sample bidirectional Mendelian randomization (MR) analysis to prioritize our results. Association analysis of prevalent type 2 diabetes revealed 24 replicated proteins, of which 8 are novel. Proteins showing association with incident type 2 diabetes were aminoacylase-1, growth hormone receptor, and insulin-like growth factor–binding protein 2. Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes. MR analysis yielded nominally significant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, and of sex hormone–binding globulin on type 2 diabetes. In conclusion, our high-throughput pro-teomics study replicated previously reported type 2 diabetes–protein associations and identified new candidate proteins possibly involved in the pathogenesis of type 2 diabetes. © 2020 by the American Diabetes Association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Elhadad, M. A.
-
Jonasson, C.
-
Huth, C.
-
Wilson, R.
-
Gieger, C.
-
Matias, P.
-
show more...
-
Grallert, H.
-
Graumann, J.
-
Gailus-Durner, V ...
-
Rathmann, W.
-
Toerne, C. V.
-
Hauck, S. M.
-
Koenig, W.
-
Sinner, M. F.
-
Oprea, Tudor I
-
Suhre, K.
-
Thorand, B.
-
Hveem, K.
-
Peters, A.
-
Waldenberger, M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Diabetes
- By the university
-
University of Gothenburg