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HPV Types in Cervic...
HPV Types in Cervical Precancer by HIV Status and Birth Region: A Population-Based Register Study
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Carlander, C. (author)
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Lagheden, C. (author)
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Eklund, C. (author)
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Kleppe, S. N. (author)
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Dzabic, M. (author)
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Wagner, P. (author)
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- Yilmaz, Aylin, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Elfgren, K. (author)
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Sonnerborg, A. (author)
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Sparen, P. (author)
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Dillner, J. (author)
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Cancer Epidemiology Biomarkers & Prevention. - 1055-9965. ; 29:12, s. 2662-2668
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Data are lacking regarding which human papillomavirus (HPV) types cause high-grade cervical neoplasia (CIN2+) in people with HIV in Europe. We assessed which HPV types are associated with CIN2+ in women living in Sweden by HIV status. Methods: The Swedish National HIV Registry, the Swedish Population Registry, and the Swedish National Cervical Screening Registry were linked. CIN2+ tissue blocks of 130 women living with HIV (WLWH) and 234 HIV-negative women, matched for country of birth (1:2), were retrieved from bio-banks and HPV genotyped. Adjusted ORs (adjOR), stratified by country of birth, were calculated using conditional logistic regression. Matching was broken for cross-group comparisons. Results: WLWH with CIN2 were less likely to have HPV16 [14% vs. 40%; adjOR 0.1; 95% confidence interval (CI), 0.04-0.56] than HIV-negative women, but among women with CIN3, there was no difference in HPV16 prevalence by HIV status (adjOR 0.9; 95% CI, 0.51-1.70). WLWH were six times more likely to have HPV35 in CIN3 than HIV-negative women (adjOR 6.2; 95% CI, 1.3-30.4). WLWH from sub-Saharan Africa (SSA) had less 9-valent vaccine types, compared with both HIV-negative women born in Sweden (adjOR 0.1; 95% CI, 0.02-0.44) and WLWH born in Sweden (adjOR 0.1; 95% CI, 0.01-0.73), mostly because of decreased HPV16 and increased HPV35. Conclusions: WLWH from SSA were less likely to be covered by the 9-valent vaccine, mostly due to less HPV16 and more HPV35. Impact: This could have implications for HPV vaccines, currently not including HPV35, and for HPV-screening algorithms in women with origin from SSA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- human-papillomavirus
- intraepithelial neoplasia
- positive women
- infected women
- multiple types
- cancer
- impact
- risk
- migrants
- health
- Oncology
- Public
- Environmental & Occupational Health
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Carlander, C.
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Lagheden, C.
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Eklund, C.
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Kleppe, S. N.
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Dzabic, M.
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Wagner, P.
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show more...
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Yilmaz, Aylin, 1 ...
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Elfgren, K.
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Sonnerborg, A.
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Sparen, P.
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Dillner, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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University of Gothenburg