Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

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Jones, G.University of Exeter (author)

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-01-28
Springer Science and Business Media LLC,2021

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LIBRIS-ID:oai:gup.ub.gu.se/302665
https://gup.ub.gu.se/publication/302665URI
https://doi.org/10.1038/s41467-021-20918-wDOI
https://lup.lub.lu.se/record/db7fca04-91ef-4f7f-b4f2-1b38c8d03076URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n=48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1p=4x10(-17)), arthritis (GDF5p=4x10(-13)), cell cycle control and cancer protection, regulation of transcription, and others involved in the development and maintenance of the musculoskeletal system. Using Mendelian randomization we report possible overlapping causal pathways, including diabetes susceptibility, haematological parameters, and the immune system. We conclude that muscle weakness in older adults has distinct mechanisms from continuous strength, including several pathways considered to be hallmarks of ageing. Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
Science & Technology - Other Topics

Added entries (persons, corporate bodies, meetings, titles ...)

Trajanoska, K. (author)
Santanasto, A. J. (author)
Stringa, N. (author)
Kuo, C. L. (author)
Atkins, J. L. (author)
Lewis, J. R. (author)
Duong, T. (author)
Hong, S. J. (author)
Biggs, M. L. (author)
Luan, J. A. (author)
Sarnowski, C. (author)
Lunetta, K. L. (author)
Tanaka, T. (author)
Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)orto-mka (author)
Cvejkus, R. (author)
Nethander, Maria,1980Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Core Facilities, Bioinformatics,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xnetma (author)
Ghasemi, S. (author)
Yang, J. Y. (author)
Zillikens, M. C. (author)
Walter, S. (author)
Sicinski, K. (author)
Kague, E. (author)
Ackert-Bicknell, C. L. (author)
Arking, D. E. (author)
Windham, B. G. (author)
Boerwinkle, E. (author)
Grove, M. L. (author)
Graff, M. (author)
Spira, D. (author)
Demuth, I. (author)
van der Velde, N. (author)
de Groot, Lcpgm (author)
Psaty, B. M. (author)
Odden, M. C. (author)
Fohner, A. E. (author)
Langenberg, C. (author)
Wareham, N. J. (author)
Bandinelli, S. (author)
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xmelda (author)
Huisman, M. (author)
Tan, Q. H. (author)
Zmuda, J. (author)
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xmelda (author)
Karlsson, M. (author)
Bennett, D. A. (author)
Buchman, A. S. (author)
De Jager, P. L. (author)
Uitterlinden, A. G. (author)
Volker, U. (author)
Kocher, T. (author)
Teumer, A. (author)
Rodriguez-Manas, L. (author)
Garcia, F. J. (author)
Carnicero, J. A. (author)
Herd, P. (author)
Bertram, L. (author)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
Murabito, J. M. (author)
Melzer, D. (author)
Kuchel, G. A. (author)
Ferrucci, L. (author)
Karasik, D. (author)
Rivadeneira, F. (author)
Kiel, D. P. (author)
Pilling, L. C.University of Exeter (author)
University of ExeterOrtopedi - klinisk och molekylär osteoporosforskning (creator_code:org_t)

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By the author/editor: Jones, G.; Trajanoska, K.; Santanasto, A. J ...; Stringa, N.; Kuo, C. L.; Atkins, J. L.; show more...; Lewis, J. R.; Duong, T.; Hong, S. J.; Biggs, M. L.; Luan, J. A.; Sarnowski, C.; Lunetta, K. L.; Tanaka, T.; Karlsson, Magnus; Cvejkus, R.; Nethander, Maria ...; Ghasemi, S.; Yang, J. Y.; Zillikens, M. C.; Walter, S.; Sicinski, K.; Kague, E.; Ackert-Bicknell, ...; Arking, D. E.; Windham, B. G.; Boerwinkle, E.; Grove, M. L.; Graff, M.; Spira, D.; Demuth, I.; van der Velde, N ...; de Groot, Lcpgm; Psaty, B. M.; Odden, M. C.; Fohner, A. E.; Langenberg, C.; Wareham, N. J.; Bandinelli, S.; Mellström, Dan, ...; Huisman, M.; Tan, Q. H.; Zmuda, J.; Karlsson, M.; Bennett, D. A.; Buchman, A. S.; De Jager, P. L.; Uitterlinden, A. ...; Volker, U.; Kocher, T.; Teumer, A.; Rodriguez-Manas, ...; Garcia, F. J.; Carnicero, J. A.; Herd, P.; Bertram, L.; Ohlsson, Claes, ...; Murabito, J. M.; Melzer, D.; Kuchel, G. A.; Ferrucci, L.; Karasik, D.; Rivadeneira, F.; Kiel, D. P.; Pilling, L. C.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

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