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- Vergallo, A. (author)
Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- Elsevier BV,2020
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/302832
- https://gup.ub.gu.se/publication/302832URI
- https://doi.org/10.1016/j.neurobiolaging.2020.07.009DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
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Notes
- Neuroinflammation, a key early pathomechanistic alteration of Alzheimer's disease, may represent either a detrimental or a compensatory mechanism or both (according to the disease stage). YKL-40, a glycoprotein highly expressed in differentiated glial cells, is a candidate biomarker for in vivo tracking neuroinflammation in humans. We performed a longitudinal study in a monocentric cohort of cognitively healthy individuals at risk for Alzheimer's disease exploring whether age, sex, and the apolipoprotein E ε4 allele affect plasma YKL-40 concentrations. We investigated whether YKL-40 is associated with brain amyloid-β (Aβ) deposition, neuronal activity, and neurodegeneration as assessed via neuroimaging biomarkers. Finally, we investigated whether YKL-40 may predict cognitive performance. We found an age-associated increase of YKL-40 and observed that men display higher concentrations than women, indicating a potential sexual dimorphism. Moreover, YKL-40 was positively associated with memory performance and negatively associated with brain Aβ deposition (but not with metabolic signal). Consistent with translational studies, our results suggest a potentially protective effect of glia on incipient brain Aβ accumulation and neuronal homeostasis. © 2020 Elsevier Inc.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Alzheimer's disease
- Amyloid
- Neuroinflammation
- Sex
- YKL-40
- amyloid beta protein
- apolipoprotein E4
- biological marker
- fluorodeoxyglucose f 18
- glycoprotein
- unclassified drug
- YKL 40 protein
- age
- aged
- Alzheimer disease
- Article
- basal forebrain
- brain cortex
- brain metabolism
- brain size
- Clinical Dementia Rating
- cognition
- cohort analysis
- controlled study
- cross-sectional study
- entorhinal cortex
- female
- follow up
- gender
- hippocampus
- human
- human cell
- longitudinal study
- major clinical study
- male
- memory
- memory disorder
- mental performance
- Mini Mental State Examination
- nervous system inflammation
- nuclear magnetic resonance imaging
- observational study
- orbital cortex
- parietal cortex
- pathogenesis
- positron emission tomography
- priority journal
- protein blood level
- right inferior parietal cortex
- risk factor
- sex difference
- subjective memory complaint
- tissue level
- very elderly
Added entries (persons, corporate bodies, meetings, titles ...)
- Lista, S. (author)
- Lemercier, P. (author)
- Chiesa, P. A. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
- Potier, M. C. (author)
- Habert, M. O. (author)
- Baldacci, F. (author)
- Cavedo, E. (author)
- Caraci, F. (author)
- Dubois, B. (author)
- Hampel, H. (author)
- Bakardjian, H. (author)
- Benali, H. (author)
- Bertin, H. (author)
- Bonheur, J. (author)
- Boukadida, L. (author)
- Boukerrou, N. (author)
- Chiesa, P. (author)
- Colliot, O. (author)
- Dubois, M. (author)
- Epelbaum, S. (author)
- Gagliardi, G. (author)
- Genthon, R. (author)
- Houot, M. (author)
- Kas, A. (author)
- Lamari, F. (author)
- Levy, M. (author)
- Metzinger, C. (author)
- Mochel, F. (author)
- Nyasse, F. (author)
- Poisson, C. (author)
- Revillon, M. (author)
- Santos, A. (author)
- Andrade, K. S. (author)
- Sole, M. (author)
- Surtee, M. (author)
- de Schotten, M. T. (author)
- Younsi, N. (author)
- Afshar, M. (author)
- Aguilar, L. F. (author)
- Akman-Anderson, L. (author)
- Arenas, J. (author)
- Ávila, J. (author)
- Babiloni, C. (author)
- Batrla, R. (author)
- Benda, N. (author)
- Black, K. L. (author)
- Bokde, A. L. W. (author)
- Bonuccelli, U. (author)
- Broich, K. (author)
- Cacciola, F. (author)
- Caruso, G. (author)
- Castrillo†, J. (author)
- Ceravolo, R. (author)
- Corbo, M. (author)
- Corvol, J. C. (author)
- Cuello, A. C. (author)
- Cummings, J. L. (author)
- Depypere, H. (author)
- Duggento, A. (author)
- Emanuele, E. (author)
- Escott-Price, V. (author)
- Federoff, H. (author)
- Ferretti, M. T. (author)
- Fiandaca, M. (author)
- Frank, R. A. (author)
- Garaci, F. (author)
- Geerts, H. (author)
- Giacobini, E. (author)
- Giorgi, F. S. (author)
- Goetzl, E. J. (author)
- Graziani, M. (author)
- Haberkamp, M. (author)
- Hänisch, B. (author)
- Herholz, K. (author)
- Hernandez, F. (author)
- Imbimbo, B. P. (author)
- Kapogiannis, D. (author)
- Karran, E. (author)
- Kiddle, S. J. (author)
- Kim, S. H. (author)
- Koronyo, Y. (author)
- Koronyo-Hamaoui, M. (author)
- Langevin, T. (author)
- Lehéricy, S. (author)
- Llavero, F. (author)
- Lorenceau, J. (author)
- Lucía, A. (author)
- Mango, D. (author)
- Mapstone, M. (author)
- Neri, C. (author)
- Nisticò, R. (author)
- O'Bryant, S. E. (author)
- Palermo, G. (author)
- Perry, G. (author)
- Ritchie, C. (author)
- Rossi, S. (author)
- Saidi, A. (author)
- Santarnecchi, E. (author)
- Schneider, L. S. (author)
- Sporns, O. (author)
- Toschi, N. (author)
- Valenzuela, P. L. (author)
- Vellas, B. (author)
- Verdooner, S. R. (author)
- Villain, N. (author)
- Giudici, K. V. (author)
- Watling, M. (author)
- Welikovitch, L. A. (author)
- Woodcock, J. (author)
- Younesi, E. (author)
- Zugaza, J. L. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
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- In:Neurobiology of Aging: Elsevier BV96, s. 22-320197-4580
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- Vergallo, A.
- Lista, S.
- Lemercier, P.
- Chiesa, P. A.
- Zetterberg, Henr ...
- Blennow, Kaj, 19 ...
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- Potier, M. C.
- Habert, M. O.
- Baldacci, F.
- Cavedo, E.
- Caraci, F.
- Dubois, B.
- Hampel, H.
- Bakardjian, H.
- Benali, H.
- Bertin, H.
- Bonheur, J.
- Boukadida, L.
- Boukerrou, N.
- Chiesa, P.
- Colliot, O.
- Dubois, M.
- Epelbaum, S.
- Gagliardi, G.
- Genthon, R.
- Houot, M.
- Kas, A.
- Lamari, F.
- Levy, M.
- Metzinger, C.
- Mochel, F.
- Nyasse, F.
- Poisson, C.
- Revillon, M.
- Santos, A.
- Andrade, K. S.
- Sole, M.
- Surtee, M.
- de Schotten, M. ...
- Younsi, N.
- Afshar, M.
- Aguilar, L. F.
- Akman-Anderson, ...
- Arenas, J.
- Ávila, J.
- Babiloni, C.
- Batrla, R.
- Benda, N.
- Black, K. L.
- Bokde, A. L. W.
- Bonuccelli, U.
- Broich, K.
- Cacciola, F.
- Caruso, G.
- Castrillo†, J.
- Ceravolo, R.
- Corbo, M.
- Corvol, J. C.
- Cuello, A. C.
- Cummings, J. L.
- Depypere, H.
- Duggento, A.
- Emanuele, E.
- Escott-Price, V.
- Federoff, H.
- Ferretti, M. T.
- Fiandaca, M.
- Frank, R. A.
- Garaci, F.
- Geerts, H.
- Giacobini, E.
- Giorgi, F. S.
- Goetzl, E. J.
- Graziani, M.
- Haberkamp, M.
- Hänisch, B.
- Herholz, K.
- Hernandez, F.
- Imbimbo, B. P.
- Kapogiannis, D.
- Karran, E.
- Kiddle, S. J.
- Kim, S. H.
- Koronyo, Y.
- Koronyo-Hamaoui, ...
- Langevin, T.
- Lehéricy, S.
- Llavero, F.
- Lorenceau, J.
- Lucía, A.
- Mango, D.
- Mapstone, M.
- Neri, C.
- Nisticò, R.
- O'Bryant, S. E.
- Palermo, G.
- Perry, G.
- Ritchie, C.
- Rossi, S.
- Saidi, A.
- Santarnecchi, E.
- Schneider, L. S.
- Sporns, O.
- Toschi, N.
- Valenzuela, P. L ...
- Vellas, B.
- Verdooner, S. R.
- Villain, N.
- Giudici, K. V.
- Watling, M.
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- Younesi, E.
- Zugaza, J. L.
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