Replication study of plasma proteins relating to Alzheimer's pathology.

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Shi, LiuDepartment of Psychiatry, University of Oxford, Oxford, UK (author)

Replication study of plasma proteins relating to Alzheimer's pathology.

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-03-31
Wiley,2021

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LIBRIS-ID:oai:gup.ub.gu.se/303351
https://gup.ub.gu.se/publication/303351URI
https://doi.org/10.1002/alz.12322DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90976URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:146304983URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF grant from the European Union's Seventh Framework Programme (FP7/2007-2013) 115372European Commission Joint Research Centre QLRT-2001-2455 37670Stichting voor Alzheimer Onderzoek 11020 13007 15005Department of Health of the Basque Government 17.0.1.08.12.0000.2.454.01.41142.001.HUniversity of Antwerp Research Fund European Research Council (ERC) European Commission 681712Swedish State Support for Clinical Research ALFGBG720931Alzheimer Drug Discovery Foundation (ADDF), USA 201809-2016862UK Dementia Research Institute at UCL NIHR biomedical research center at UCLH EFPIA companies'
This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
ATN framework

Added entries (persons, corporate bodies, meetings, titles ...)

Winchester, Laura M (author)
Westwood, Sarah (author)
Baird, Alison L (author)
Anand, Sneha N (author)
Buckley, Noel J (author)
Hye, Abdul (author)
Ashton, Nicholas J (author)
Bos, Isabelle (author)
Vos, Stephanie J B (author)
Kate, Mara Ten (author)
Scheltens, Philip (author)
Teunissen, Charlotte E (author)
Vandenberghe, Rik (author)
Gabel, Silvy (author)
Meersmans, Karen (author)
Engelborghs, Sebastiaan (author)
De Roeck, Ellen E (author)
Sleegers, Kristel (author)
Frisoni, Giovanni B (author)
Blin, Olivier (author)
Richardson, Jill C (author)
Bordet, Régis (author)
Molinuevo, José L (author)
Rami, Lorena (author)
Wallin, Anders (author)
Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xketpe (author)
Tsolaki, Magda (author)
Verhey, Frans (author)
Lléo, Alberto (author)
Sala, Isabel (author)
Popp, JuliusKarolinska Institutet (author)
Peyratout, Gwendoline (author)
Martinez-Lage, Pablo (author)
Tainta, Mikel (author)
Johannsen, Peter (author)
Freund-Levi, Yvonne,1956-Örebro universitet,Institutionen för medicinska vetenskaper,Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, Stockholm, Sweden; Department of Neurobiology, Caring Sciences and Society (NVS), Stockholm, Sweden(Swepub:oru)yfi (author)
Frölich, Lutz (author)
Dobricic, Valerija (author)
Legido-Quigley, Cristina (author)
Barkhof, Frederik (author)
Andreasson, Ulf (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Streffer, Johannes (author)
Lill, Christina M (author)
Bertram, Lars (author)
Visser, Pieter Jelle (author)
Kolb, Hartmuth C (author)
Narayan, Vaibhav A (author)
Lovestone, Simon (author)
Nevado-Holgado, Alejo JDepartment of Psychiatry, University of Oxford, Oxford, UK (author)
Department of Psychiatry, University of Oxford, Oxford, UKInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley17:9, s. 1452-14641552-52791552-5260
In:Alzheimer's & Dementia: Wiley17:9, s. 1452-14641552-5260

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By the author/editor: Shi, Liu; Winchester, Laur ...; Westwood, Sarah; Baird, Alison L; Anand, Sneha N; Buckley, Noel J; show more...; Hye, Abdul; Ashton, Nicholas ...; Bos, Isabelle; Vos, Stephanie J ...; Kate, Mara Ten; Scheltens, Phili ...; Teunissen, Charl ...; Vandenberghe, Ri ...; Gabel, Silvy; Meersmans, Karen; Engelborghs, Seb ...; De Roeck, Ellen ...; Sleegers, Kriste ...; Frisoni, Giovann ...; Blin, Olivier; Richardson, Jill ...; Bordet, Régis; Molinuevo, José ...; Rami, Lorena; Wallin, Anders; Kettunen, Petron ...; Tsolaki, Magda; Verhey, Frans; Lléo, Alberto; Sala, Isabel; Popp, Julius; Peyratout, Gwend ...; Martinez-Lage, P ...; Tainta, Mikel; Johannsen, Peter; Freund-Levi, Yvo ...; Frölich, Lutz; Dobricic, Valeri ...; Legido-Quigley, ...; Barkhof, Frederi ...; Andreasson, Ulf; Blennow, Kaj, 19 ...; Zetterberg, Henr ...; Streffer, Johann ...; Lill, Christina ...; Bertram, Lars; Visser, Pieter J ...; Kolb, Hartmuth C; Narayan, Vaibhav ...; Lovestone, Simon; Nevado-Holgado, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

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