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Plasma pTau181 pred...
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease.
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Tissot, Cécile (author)
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Lessa Benedet, Andréa (author)
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Therriault, Joseph (author)
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Pascoal, Tharick A (author)
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Lussier, Firoza Z (author)
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Saha-Chaudhuri, Paramita (author)
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Chamoun, Mira (author)
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Savard, Melissa (author)
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Mathotaarachchi, Sulantha S (author)
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Bezgin, Gleb (author)
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Wang, Yi-Ting (author)
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Fernandez Arias, Jaime (author)
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Rodriguez, Juan, 1983 (author)
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- Snellman, Anniina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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De Villers-Sidani, Etienne (author)
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Huot, Philippe (author)
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Gauthier, Serge (author)
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Rosa-Neto, Pedro (author)
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(creator_code:org_t)
- 2021-03-29
- 2021
- English.
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In: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 13:1
- Related links:
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https://alzres.biome...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and longitudinally, in aging and Alzheimer's disease.Observational data was obtained from the Alzheimer's Disease Neuroimaging Initiative, in which participants underwent plasma assessment and magnetic resonance imaging. Based on their clinical diagnosis, participants were classified as cognitively unimpaired and cognitively impaired. Linear regressions and linear mixed-effect models were used to test the cross-sectional and longitudinal associations between baseline plasma pTau181 and neurodegeneration using voxel-based morphometry.We observed a negative correlation at baseline between plasma pTau181 and gray matter volume in cognitively unimpaired individuals. In cognitively impaired individuals, we observed a negative association between plasma pTau181 and both gray and white matter volume. In longitudinal analyses conducted in the cognitively unimpaired group, plasma pTau181 was negatively correlated with gray matter volume, starting 36months after baseline assessments. Finally, in cognitively impaired individuals, plasma pTau181 concentrations were negatively correlated with both gray and white matter volume as early as 12months after baseline, and neurodegeneration increased in an incremental manner until 48months.Higher levels of plasma pTau181 correlate with neurodegeneration and predict further brain atrophy in aging and Alzheimer's disease. Plasma pTau181 may be useful in predicting AD-related neurodegeneration, comparable to positron emission tomography or cerebrospinal fluid assessment with high specificity for AD neurodegeneration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- Neurodegeneration
- Plasma pTau181
- Voxel-based morphometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tissot, Cécile
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Lessa Benedet, A ...
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Therriault, Jose ...
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Pascoal, Tharick ...
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Lussier, Firoza ...
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Saha-Chaudhuri, ...
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show more...
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Chamoun, Mira
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Savard, Melissa
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Mathotaarachchi, ...
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Bezgin, Gleb
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Wang, Yi-Ting
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Fernandez Arias, ...
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Rodriguez, Juan, ...
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Snellman, Anniin ...
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Ashton, Nicholas ...
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Karikari, Thomas
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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De Villers-Sidan ...
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Huot, Philippe
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Gauthier, Serge
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Rosa-Neto, Pedro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's Rese ...
- By the university
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University of Gothenburg