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Impact of sex and A...
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Wang, RuiKarolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Karolinska Institutet and Stockholm University, Stockholm, Sweden,Fysisk aktivitet och hjärnhälsa
(författare)
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults : A longitudinal study.
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Sage Publications,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:gih-6750
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6750URI
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https://doi.org/10.1177/0271678X211021313DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147271398URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Oh, Jennifer MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Middleton Memorial Veterans Hospital, Madison, WI, USA.
(författare)
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Motovylyak, AliceUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Ma, YueUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Sager, Mark AUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Rowley, Howard AUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Johnson, Kevin MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Gallagher, Catherine LUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Carlsson, Cynthia MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Bendlin, Barbara BUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Johnson, Sterling CUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Asthana, SanjayUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Eisenmenger, LauraUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Okonkwo, Ozioma CUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
(författare)
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Gymnastik- och idrottshögskolanInstitutionen för fysisk aktivitet och hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Cerebral Blood Flow and Metabolism: Sage Publications41:11, s. 3016-30270271-678X1559-7016
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Wang, Rui
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Oh, Jennifer M
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Motovylyak, Alic ...
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Ma, Yue
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Sager, Mark A
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Rowley, Howard A
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visa fler...
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Johnson, Kevin M
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Gallagher, Cathe ...
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Carlsson, Cynthi ...
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Bendlin, Barbara ...
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Johnson, Sterlin ...
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Asthana, Sanjay
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Eisenmenger, Lau ...
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Okonkwo, Ozioma ...
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Gymnastik- och idrottshögskolan
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Karolinska Institutet