Search: (WFRF:(Martins Ralph N)) pers:(Zetterberg Henrik 1973) >
Plasma glial fibril...
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Chatterjee, Pratishtha
(author)
Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-11
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/303580
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https://gup.ub.gu.se/publication/303580URI
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https://doi.org/10.1038/s41398-020-01137-1DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in blood samples, and has been associated with Alzheimer's disease (AD). However, plasma GFAP has not been investigated in cognitively normal older adults at risk of AD, based on brain amyloid-β (Aβ) load. Cross-sectional analyses were carried out for plasma GFAP and plasma Aβ1-42/Aβ1-40 ratio, a blood-based marker associated with brain Aβ load, in participants (65-90 years) categorised into low (Aβ-, n=63) and high (Aβ+, n=33) brain Aβ load groups via Aβ positron emission tomography. Plasma GFAP, Aβ1-42, and Aβ1-40 were measured using the Single molecule array (Simoa) platform. Plasma GFAP levels were significantly higher (p<0.00001), and plasma Aβ1-42/Aβ1-40 ratios were significantly lower (p<0.005), in Aβ+ participants compared to Aβ- participants, adjusted for covariates age, sex, and apolipoprotein E-ε4 carriage. A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished Aβ+ from Aβ- (area under the curve, AUC=0.78), but was outperformed when plasma GFAP was added to the base model (AUC=0.91) and further improved with plasma Aβ1-42/Aβ1-40 ratio (AUC=0.92). The current findings demonstrate that plasma GFAP levels are elevated in cognitively normal older adults at risk of AD. These observations suggest that astrocytic damage or activation begins from the pre-symptomatic stage of AD and is associated with brain Aβ load. Observations from the present study highlight the potential of plasma GFAP to contribute to a diagnostic blood biomarker panel (along with plasma Aβ1-42/Aβ1-40 ratios) for cognitively normal older adults at risk of AD.
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Pedrini, Steve
(author)
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Stoops, Erik
(author)
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Goozee, Kathryn
(author)
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Villemagne, Victor L
(author)
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Asih, Prita R
(author)
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Verberk, Inge M W
(author)
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Dave, Preeti
(author)
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Taddei, Kevin
(author)
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Sohrabi, Hamid R
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Teunissen, Charlotte E
(author)
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Vanderstichele, Hugo M
(author)
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Martins, Ralph N
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Translational psychiatry: Springer Science and Business Media LLC11:12158-3188
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Chatterjee, Prat ...
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Pedrini, Steve
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Stoops, Erik
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Goozee, Kathryn
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Villemagne, Vict ...
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Asih, Prita R
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Verberk, Inge M ...
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Dave, Preeti
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Taddei, Kevin
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Sohrabi, Hamid R
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Teunissen, Charl ...
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Vanderstichele, ...
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Martins, Ralph N
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