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  • Borrelli, P.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (författare)

AI-based detection of lung lesions in F-18 FDG PET-CT from lung cancer patients

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-03-25
  • Springer Science and Business Media LLC,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/303884
  • https://gup.ub.gu.se/publication/303884URI
  • https://doi.org/10.1186/s40658-021-00376-5DOI
  • https://research.chalmers.se/publication/523277URI
  • https://lup.lub.lu.se/record/64bca0a6-ae9f-46dc-81b5-2b650deb861dURI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background[F-18]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent research efforts have focused on extracting theragnostic and textural information from manually indicated lung lesions. Both semi-automatic and fully automatic use of artificial intelligence (AI) to localise and classify FDG-avid foci has been demonstrated. To fully harness AI's usefulness, we have developed a method which both automatically detects abnormal lung lesions and calculates the total lesion glycolysis (TLG) on FDG PET-CT.MethodsOne hundred twelve patients (59 females and 53 males) who underwent FDG PET-CT due to suspected or for the management of known lung cancer were studied retrospectively. These patients were divided into a training group (59%; n = 66), a validation group (20.5%; n = 23) and a test group (20.5%; n = 23). A nuclear medicine physician manually segmented abnormal lung lesions with increased FDG-uptake in all PET-CT studies. The AI-based method was trained to segment the lesions based on the manual segmentations. TLG was then calculated from manual and AI-based measurements, respectively and analysed with Bland-Altman plots.ResultsThe AI-tool's performance in detecting lesions had a sensitivity of 90%. One small lesion was missed in two patients, respectively, where both had a larger lesion which was correctly detected. The positive and negative predictive values were 88% and 100%, respectively. The correlation between manual and AI TLG measurements was strong (R-2 = 0.74). Bias was 42 g and 95% limits of agreement ranged from -736 to 819 g. Agreement was particularly high in smaller lesions.ConclusionsThe AI-based method is suitable for the detection of lung lesions and automatic calculation of TLG in small- to medium-sized tumours. In a clinical setting, it will have an added value due to its capability to sort out negative examinations resulting in prioritised and focused care on patients with potentially malignant lesions.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ly, JohnLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Nuclear medicine, Malmö,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Central Hospital Kristianstad(Swepub:lu)med-jnl (författare)
  • Kaboteh, R.Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (författare)
  • Ulén, JohannesEigenvision AB(Swepub:lu)math-jsu (författare)
  • Enqvist, Olof,1981Chalmers University of Technology,Eigenvision AB(Swepub:cth)enolof (författare)
  • Trägårdh, ElinLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Nuclear medicine, Malmö,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)klin-etr (författare)
  • Edenbrandt, Lars,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital(Swepub:lu)klfy-led (författare)
  • Sahlgrenska universitetssjukhusetSahlgrenska University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Ejnmmi Physics: Springer Science and Business Media LLC8:12197-7364

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