Funding Agencies:Lund Medical Faculty (ALF) Skåne University Hospital Research FundsGyllenstierna Krapperup's Foundation Cancer Research Fund at Malmö General Hospital Stiftelsen Sigurd och Elsa Goljes Minne Bergqvist Foundation Skåne County Council's Research and Development Foundation REGSKANE622351Gösta Jonsson Research Foundation Foundation of Urological Research Hillevi Fries Research Foundation
Funding Agencies|Swedish Cancer SocietySwedish Cancer Society [CAN 2019/62, CAN 2017/278]; Lund Medical Faculty (ALF); Skane University Hospital Research Funds; Gyllenstierna Krapperups Foundation; Cancer Research Fund at Malmo General Hospital; Stiftelsen Sigurd och Elsa Goljes Minne; Bergqvist Foundation; Skane County Councils Research and Development Foundation [REGSKANE622351]; Gosta Jonsson Research Foundation; Foundation of Urological Research; Hillevi Fries Research Foundation
Objective To assess the value of second-look resection (SLR) in stage T1 bladder cancer (BCa) with respect to progression-free survival (PFS), and also the secondary outcomes recurrence-free survival (RFS), bladder-cancer-specific survival (CSS), and cystectomy-free survival (CFS). Patients and methods The study included 2456 patients diagnosed with stage T1 BCa 2004-2009 with 5-yr follow-up registration in the nationwide Bladder Cancer Data Base Sweden (BladderBaSe). PFS, RFS, CSS, and CFS were evaluated in stage T1 BCa patients with or without routine SLR, using univariate and multivariable Cox regression with adjustment for multiple confounders (age, gender, tumour grade, intravesical treatment, hospital volume, comorbidity, and educational level). Results SLR was performed in 642 (26%) individuals, and more frequently on patients who were aged < 75 yr, had grade 3 tumours, and had less comorbidity. There was no association between SLR and PFS (hazard ratio [HR] 1.1, confidence interval [CI] 0.85-1.3), RFS (HR 1.0, CI 0.90-1.2), CFS (HR 1.2, CI 0.95-1.5) or CSS (HR 1.1, CI 0.89-1.4). Conclusions We found similar survival outcomes in patients with and patients without SLR, but our study is likely affected by selection mechanisms. A randomised study defining the role of SLR in stage T1 BCa would be highly relevant to guide current praxis.
Hagberg, OskarLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Lund Univ, Inst Translat Med, Malmö, Sweden(Swepub:lu)mats-oha
(författare)
Abdul-Sattar Aljabery, FirasLinköpings universitet,Linköping University,Linköping Univ, Div Urol, Dept Clin & Expt Med, Linköping, Sweden,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)firab05
(författare)
Gardmark, T.Karolinska Institutet,Karolinska Institute,Danderyd Hospital,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden
(författare)
Jahnson, StaffanLinköpings universitet,Linköping University,Linköping Univ, Div Urol, Dept Clin & Expt Med, Linköping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)staja74
(författare)
Jerlström, Tomas,1969-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Dept Urol, Örebro, Sweden(Swepub:oru)tjm
(författare)
Ströck, VivekaUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Sahlgrenska University Hospital and Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Univ Hosp, Dept Urol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Gothenburg, Sweden(Swepub:gu)xstrvi
(författare)