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Heart failure relat...
Heart failure related to adult congenital heart disease: prevalence, outcome and risk factors.
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Arnaert, Stijn (author)
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De Meester, Pieter (author)
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Troost, Els (author)
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Droogne, Walter (author)
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Van Aelst, Lucas (author)
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Van Cleemput, Johan (author)
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Voros, Gabor (author)
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Gewillig, Marc (author)
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Cools, Bjorn (author)
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- Moons, Philip, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences
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Rega, Filip (author)
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Meyns, Bart (author)
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Zhang, Zhenyu (author)
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Budts, Werner (author)
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Van De Bruaene, Alexander (author)
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(creator_code:org_t)
- 2021-05-07
- 2021
- English.
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In: ESC heart failure. - : Wiley. - 2055-5822. ; 8:4, s. 2940-2950
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Information on the prevalence, outcome and factors associated with heart failure in patients with adult congenital heart disease (CHD) (ACHD-HF) is lacking. We aimed at assessing the prevalence and outcome of ACHD-HF, the variables associated with ACHD-HF, and the differences between major anatomical/pathophysiological ACHD subgroups.We included 3905 patients (age 35.4±13.2years) under active follow-up in our institution (last visit >2010). Outcome of ACHD-HF cases was compared with sex- and age-matched cases. Univariable and multivariable binary logistic regression with ACHD-HF diagnosis as a dependent variable was performed. Overall prevalence of ACHD-HF was 6.4% (mean age 49.5±16.7years), but was higher in patients with cyanotic CHD (41%), Fontan circulation (30%), and a systemic right ventricle (25%). All-cause mortality was higher in ACHD-HF cases when compared with controls (mortality rate ratio 4.67 (2.36-9.27); P=0.0001). In multivariable logistic regression analysis, age at latest follow-up [per 10years; odds ratio (OR) 1.52; 95% confidence interval (CI) 1.31-1.77], infective endocarditis (OR 4.11; 95%CI 1.80-9.38), history of atrial arrhythmia (OR 3.52; 95%CI 2.17-5.74), pacemaker implantation (OR 2.66; 95% CI 1.50-4.72), end-organ dysfunction (OR 2.41; 95% CI 1.03-5.63), New York Heart Association class (OR 9.28; 95% CI 6.04-14.25), heart rate (per 10bpm; OR 1.27; 95% CI 1.08-1.50), ventricular dysfunction (OR 3.62; 95% CI 2.54-5.17), and pulmonary hypertension severity (OR 1.66; 95% CI 1.21-2.30) were independently related to the presence of ACHD-HF. Some variables (age, atrial arrhythmia, pacemaker, New York Heart Association, and ventricular dysfunction) were related to ACHD-HF in all anatomical/physiological subgroups, whereas others were not.ACHD-HF is prevalent especially in complex CHD and is associated with poor prognosis. Our data provide insight in the factors related to ACHD-HF including differences between specific anatomical and physiological subgroups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Arnaert, Stijn
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De Meester, Piet ...
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Troost, Els
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Droogne, Walter
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Van Aelst, Lucas
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Van Cleemput, Jo ...
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show more...
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Voros, Gabor
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Gewillig, Marc
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Cools, Bjorn
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Moons, Philip, 1 ...
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Rega, Filip
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Meyns, Bart
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Zhang, Zhenyu
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Budts, Werner
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Van De Bruaene, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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ESC heart failur ...
- By the university
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University of Gothenburg